{"id":"W2051778548","doi":"10.1016/j.ejca.2011.03.016","title":"Heterogeneity in the definition of dose-limiting toxicity in phase I cancer clinical trials of molecularly targeted agents: A review of the literature","year":2011,"lang":"en","type":"review","venue":"European Journal of Cancer","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Toxicity; Medicine; Limiting; Clinical trial; Maximum tolerated dose; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.08438427,0.0004041379,0.006354876,0.0001878173,0.00002230573,0.00001828744,0.001357578,0.0002134685,0.0002504059],"category_scores_gemma":[0.2063113,0.0002016504,0.002682263,0.0009420593,0.0002782973,0.00007339847,0.0001618259,0.001833757,7.857742e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009487111,"about_ca_system_score_gemma":0.0005660703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000976812,"about_ca_topic_score_gemma":0.00001151169,"domain_scores_codex":[0.9122388,0.071578,0.01460943,0.0003575133,0.0009253833,0.000290895],"domain_scores_gemma":[0.9516775,0.0294406,0.01726976,0.0007585563,0.0007569148,0.00009667815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003477455,0.0009899031,0.00006107693,0.08454215,0.0007640629,0.0001085149,0.0003612577,6.148697e-7,0.00002400982,0.001697728,0.0009231641,0.9101798],"study_design_scores_gemma":[0.00522769,0.0008131956,0.0003402725,0.9005855,0.005944732,0.00004798927,0.00002725176,0.000002050301,0.0001844978,0.02277522,0.06363264,0.000418912],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006303104,0.9947671,0.0009738254,0.00009826422,0.0008705108,0.00140879,0.0008299723,0.000002636047,0.0004186145],"genre_scores_gemma":[0.0003120798,0.970837,0.02791283,0.0003813117,0.0004617973,0.00002757341,0.000002699889,0.00006101979,0.00000372005],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9097609,"threshold_uncertainty_score":0.9428191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8118245039593,"score_gpt":0.6537769044671239,"score_spread":0.1580475994921761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}