{"id":"W2051806959","doi":"10.1056/nejmoa041892","title":"Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease","year":2005,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":962,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Histone deacetylase 2; Medicine; COPD; Histone deacetylase 5; Histone deacetylase; Proinflammatory cytokine; Acetylation; HDAC8; Immunology; Histone; Histone acetyltransferase; Cancer research; Inflammation; Internal medicine; Pathology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006292122,0.0001734076,0.0002969503,0.0002121023,0.00004447472,0.000005520164,0.0002187831,0.00009104271,0.0001172344],"category_scores_gemma":[0.0006263459,0.0001382618,0.00008872605,0.0001581505,0.0001910269,0.0000159533,0.00004771918,0.0003951176,0.000006904083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000392172,"about_ca_system_score_gemma":0.0009266471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001296317,"about_ca_topic_score_gemma":0.0003160489,"domain_scores_codex":[0.998485,0.0001900872,0.0003805189,0.0002218799,0.0004313671,0.0002911084],"domain_scores_gemma":[0.9987442,0.00005945151,0.0002058484,0.0002544286,0.0001411827,0.0005948192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002966048,0.0001782931,0.0009174664,0.00003175764,0.00003701253,0.0005310813,0.0001371337,0.000859158,0.811785,0.00001033039,0.005659201,0.1768875],"study_design_scores_gemma":[0.07032964,0.002885176,0.05110157,0.000688492,0.0001450939,0.001933239,0.0001119317,0.001058556,0.4621674,0.0002699474,0.4086313,0.0006776431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888117,0.006271419,0.0004250909,0.003355458,0.000172182,0.0001671121,0.000005199474,0.000004123341,0.0007876736],"genre_scores_gemma":[0.9921165,0.0004017651,0.0002414969,0.0001206856,0.006131521,0.000004854242,0.00001607892,0.00002251847,0.0009446548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4029721,"threshold_uncertainty_score":0.5638154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181092457541455,"score_gpt":0.3005315457419667,"score_spread":0.2887206211665521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}