{"id":"W2051806959","doi":"10.1056/nejmoa041892","title":"Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease","year":2005,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":962,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Histone deacetylase 2; Medicine; COPD; Histone deacetylase 5; Histone deacetylase; Proinflammatory cytokine; Acetylation; HDAC8; Immunology; Histone; Histone acetyltransferase; Cancer research; Inflammation; Internal medicine; Pathology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002249279,0.0002581486,0.0002585159,0.0004788169,0.0001893845,0.0002431601,0.0001744756,0.0002978156,0.001080132],"category_scores_gemma":[0.0003179422,0.00008005762,0.0001982855,0.0004098609,0.0002283083,0.0001066271,0.0001749304,0.0003307286,0.0001974874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263431,"about_ca_system_score_gemma":0.0001701501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218913,"about_ca_topic_score_gemma":0.001710562,"domain_scores_codex":[0.9998629,0.00001980401,0.00001457938,0.00004026349,0.00004029007,0.00002219328],"domain_scores_gemma":[0.9997774,0.00002593614,0.0000948938,0.00000989466,0.00004902093,0.00004289723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001926568,0.000172359,0.589175,0.001112185,0.0004040874,0.0007865602,0.0001885211,0.0003810649,0.348082,0.0002459324,0.001235923,0.05628986],"study_design_scores_gemma":[0.00002523094,0.0003166382,0.9848712,0.00004124488,0.00007027583,0.00107877,0.000052926,0.000208851,0.01036138,0.0001309735,0.002836163,0.000006334869],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.942652,0.05286175,0.000913643,0.0004445652,0.0000920013,0.0000324803,0.0009289024,0.00003345701,0.002041049],"genre_scores_gemma":[0.9936226,0.004708022,0.0004155473,0.0001004842,0.00006416079,0.00001352136,0.0006165222,0.000002637711,0.0004564599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218913,"threshold_uncertainty_score":0.003613353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181092457541455,"score_gpt":0.3005315457419667,"score_spread":0.2887206211665521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}