{"id":"W2051821508","doi":"10.1186/cc14058","title":"Immunomodulation and infection: identification of small molecule TLR3 blockers to combat deleterious inflammation in pneumonia","year":2014,"lang":"en","type":"article","venue":"Critical Care","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Children's Health Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina; Financiadora de Estudos e Projetos; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Japan Society for the Promotion of Science; Russian Foundation for Basic Research; London Health Sciences Centre","keywords":"Medicine; TLR3; Immune system; Pneumonia; Inflammation; Immunology; Sepsis; Toll-like receptor; Cytokine; Innate immune system; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002238979,0.0003765603,0.0003164013,0.0002792162,0.0001347697,0.0003096357,0.0001981338,0.0003279283,0.001263581],"category_scores_gemma":[0.0001254175,0.0001095604,0.0002900328,0.0001296229,0.0001803084,0.000281339,0.0001933138,0.0005828122,0.0002931802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001829614,"about_ca_system_score_gemma":0.0002302486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001533947,"about_ca_topic_score_gemma":0.0004243643,"domain_scores_codex":[0.9999268,0.00002013863,0.000004660245,0.000009720181,0.00001281942,0.00002579897],"domain_scores_gemma":[0.9999331,0.00001333576,0.00001748938,0.000004723698,0.000009427491,0.00002181505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004857714,0.0003613253,0.0001695903,0.0001591166,0.0000157857,0.00009524067,0.00002027145,0.0003035707,0.9836578,0.0002920466,0.0001793347,0.01426016],"study_design_scores_gemma":[0.0004512941,0.01071777,0.003723167,0.00005633728,0.00008831399,0.0007452414,0.00003275796,0.001409844,0.9726203,0.0002397397,0.009895194,0.00002005083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635279,0.02242454,0.008513679,0.0005005273,0.0001056935,0.0002953536,0.0003246244,0.0001177714,0.004189934],"genre_scores_gemma":[0.9799616,0.01095903,0.005931335,0.0003484861,0.00006907131,0.0001702649,0.000336309,0.00001725415,0.002206654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263581,"threshold_uncertainty_score":0.004227102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008472333326248329,"score_gpt":0.2509146003455887,"score_spread":0.2424422670193404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}