{"id":"W2051822015","doi":"10.1161/circulationaha.111.067306","title":"Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation","year":2012,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":622,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; British Heart Foundation","keywords":"Afterdepolarization; Ryanodine receptor; Ryanodine receptor 2; Internal medicine; Calmodulin; Endocrinology; Calsequestrin; Medicine; Phospholamban; Endoplasmic reticulum; Protein kinase A; Calcium; Chemistry; Kinase; Repolarization; Biochemistry; Electrophysiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377906,0.0003419942,0.0004611126,0.0002830858,0.0002130309,0.0002801738,0.0001073198,0.0003007135,0.001144947],"category_scores_gemma":[0.0006437188,0.0001137444,0.0001552535,0.0002478021,0.0002452273,0.0001977467,0.0001337205,0.0002590421,0.0001607278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001297431,"about_ca_system_score_gemma":0.000073804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002906656,"about_ca_topic_score_gemma":0.0003414208,"domain_scores_codex":[0.9998915,0.00001288053,0.00002234078,0.00003854278,0.00001805575,0.00001671695],"domain_scores_gemma":[0.9996595,0.00007153174,0.0001790154,0.0000199062,0.00002407204,0.00004591428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002005613,0.00006910988,0.924812,0.00008556236,0.00008811807,0.001670779,0.0002787214,0.0001193643,0.0601612,0.00005715821,0.0001621711,0.01049025],"study_design_scores_gemma":[0.00002706728,0.0002201943,0.9923431,0.000005414973,0.00004345868,0.004829534,0.00007521787,0.000219759,0.00201137,0.00005739462,0.0001644806,0.000002977371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992699,0.0003373563,0.0001723829,0.00002526253,0.000002411792,0.000003129096,0.00007353986,0.000006001189,0.0001100227],"genre_scores_gemma":[0.9996344,0.00009141771,0.0001003338,0.00001257939,0.00001099464,0.000003016711,0.0001029017,0.000001886032,0.00004252786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001144947,"threshold_uncertainty_score":0.003830254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00692622076819741,"score_gpt":0.2163518636902917,"score_spread":0.2094256429220943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}