{"id":"W2051827896","doi":"10.1158/0008-5472.sabcs11-ot1-02-02","title":"OT1-02-02: HALT MBC: HER2 Suppression with the Addition of Lapatinib to Trastuzumab in HER2−Positive Metastatic Breast Cancer (LPT112515).","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Lapatinib; Trastuzumab; Medicine; Metastatic breast cancer; Internal medicine; Oncology; Breast cancer; Discontinuation; Paclitaxel; Cancer; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000664146,0.0007947486,0.001216191,0.0003316822,0.000250072,0.0006812236,0.0007555226,0.0008958669,0.004886766],"category_scores_gemma":[0.0003629778,0.0002914712,0.0006720572,0.0003636658,0.0006628897,0.0005857953,0.0002732289,0.002214725,0.0006540967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006228609,"about_ca_system_score_gemma":0.00111687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001197207,"about_ca_topic_score_gemma":0.003051878,"domain_scores_codex":[0.9997798,0.00006957084,0.00001553748,0.00003271516,0.00002651639,0.00007602426],"domain_scores_gemma":[0.999787,0.00002589798,0.00004458881,0.00001638214,0.000009838788,0.0001161983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5251893,0.08593714,0.005480137,0.001660639,0.0008003297,0.0007575354,0.0002424843,0.002264278,0.1989932,0.001030583,0.008163336,0.1694811],"study_design_scores_gemma":[0.3317225,0.6190565,0.01238678,0.00007558712,0.000483683,0.0007495857,0.0000750648,0.001427219,0.02732968,0.0002194112,0.006433781,0.00004029122],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942523,0.001538626,0.0001837685,0.0003868575,0.0001225111,0.0009023569,0.0007352594,0.00008230361,0.001796024],"genre_scores_gemma":[0.9916247,0.00135471,0.0006774113,0.0003805012,0.0001194099,0.0009835688,0.001719177,0.00001798008,0.003122549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004886766,"threshold_uncertainty_score":0.01634789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1375386825192163,"score_gpt":0.4509132527718353,"score_spread":0.3133745702526191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}