{"id":"W2051858387","doi":"10.1016/j.jmb.2010.03.064","title":"The Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1","year":2010,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Zymeworks (Canada)","funders":"National Center for Research Resources; National Institute of Environmental Health Sciences; Hormel Foundation; National Cancer Institute; Basic Energy Sciences; Foundation for the National Institutes of Health","keywords":"Protein kinase A; Protein kinase R; Terminal (telecommunication); Chemistry; Mitogen-activated protein kinase kinase; Mitogen-activated protein kinase; Kinase; ASK1; Cell biology; Biochemistry; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002980454,0.0004433226,0.0005439236,0.0001657409,0.0005097684,0.0009735438,0.0009373789,0.0006248981,0.002048786],"category_scores_gemma":[0.0005788664,0.0002970505,0.0001877367,0.0004041244,0.0003274282,0.0005468678,0.0002005696,0.002150782,0.0005327279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00132764,"about_ca_system_score_gemma":0.001398786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00483764,"about_ca_topic_score_gemma":0.006272101,"domain_scores_codex":[0.999911,0.000008257528,0.000004337771,0.00001579827,0.00003791525,0.00002277884],"domain_scores_gemma":[0.9998354,0.00004645269,0.00002758364,0.000007065192,0.00003706633,0.00004653556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005060377,0.001510466,0.01137942,0.002738349,0.0003179357,0.00494967,0.001431043,0.02344981,0.7342839,0.02889341,0.1051699,0.08081581],"study_design_scores_gemma":[0.003486438,0.001362886,0.06933232,0.0004882128,0.0005682923,0.005792588,0.00234288,0.108315,0.4735756,0.01310923,0.3211426,0.0004840156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9455463,0.01558218,0.006388112,0.004501737,0.001650904,0.0001346992,0.007233435,0.000400973,0.01856174],"genre_scores_gemma":[0.948944,0.009037532,0.008744114,0.0008524728,0.0001772676,0.0001058282,0.01946065,0.00008150745,0.01259664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00483764,"threshold_uncertainty_score":0.009632707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003750878836840432,"score_gpt":0.2247810268377231,"score_spread":0.2210301480008827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}