{"id":"W2051859926","doi":"10.1016/j.ydbio.2011.04.029","title":"Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos","year":2011,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"March of Dimes Foundation","keywords":"Gastrulation; Wnt signaling pathway; Biology; Mutant; Cell biology; Endoderm; Embryonic stem cell; WNT3A; Zebrafish; Genetics; Epiblast; Mesoderm; Beta-catenin; Embryo; Embryogenesis; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719715,0.0004491118,0.0003353361,0.0008121793,0.0004061187,0.0007256994,0.0006373643,0.0006779862,0.003596616],"category_scores_gemma":[0.0003738225,0.0006582993,0.0003402462,0.0001972151,0.000597246,0.0004424553,0.0006020511,0.0008744528,0.001073673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004411105,"about_ca_system_score_gemma":0.0003156514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118669,"about_ca_topic_score_gemma":0.002156849,"domain_scores_codex":[0.9996783,0.00002342947,0.00002595331,0.00008724754,0.0001287449,0.00005644347],"domain_scores_gemma":[0.99943,0.00009268017,0.0002183559,0.0000705574,0.00003375922,0.0001546628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008608784,0.000007703471,0.0001605565,0.00001687346,0.000003660797,0.0004412727,0.00001194682,0.00003281829,0.9984842,0.0002050578,0.00002815803,0.0005217016],"study_design_scores_gemma":[0.00003223047,0.00004056618,0.009578934,0.00001146041,0.00002630364,0.002198263,0.00004864192,0.0007399253,0.9825284,0.0001559855,0.004629854,0.000009359944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848681,0.001407515,0.00753438,0.0001847288,0.00007374864,0.00002719291,0.0006810952,0.0005081581,0.004715072],"genre_scores_gemma":[0.9846865,0.0005638147,0.00277784,0.00008335894,0.00001897199,0.00003655458,0.0008631013,0.0003375361,0.01063237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003596616,"threshold_uncertainty_score":0.01203185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03246080682384647,"score_gpt":0.2607329942328639,"score_spread":0.2282721874090175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}