{"id":"W2051869406","doi":"10.1016/j.neuint.2011.07.002","title":"Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents","year":2011,"lang":"en","type":"article","venue":"Neurochemistry International","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":147,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Centre for Addiction and Mental Health","keywords":"Dopamine receptor D3; Chemistry; Pharmacology; Partial agonist; Agonist; ED50; Catalepsy; Dopamine receptor D2; Endocrinology; Dopamine; Internal medicine; Receptor; Medicine; Biochemistry; Haloperidol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203513,0.000436114,0.0003153287,0.0002675042,0.0001649863,0.0001400893,0.0001754169,0.0002602564,0.001221378],"category_scores_gemma":[0.0001072152,0.0001950259,0.0001603205,0.0001752262,0.0002583899,0.0001316305,0.00009972517,0.0003956351,0.0004904274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002205803,"about_ca_system_score_gemma":0.0002103248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001988843,"about_ca_topic_score_gemma":0.004149923,"domain_scores_codex":[0.9999405,0.00001425212,0.000002651078,0.000008778055,0.00001410508,0.00001978761],"domain_scores_gemma":[0.9999007,0.00001777798,0.00003614099,0.000008983078,0.000006723993,0.00002974127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001538189,0.0001174507,0.0007385203,0.00009965333,0.00003593995,0.0001513764,0.00002048904,0.000212814,0.9835793,0.0002217172,0.000403606,0.01288072],"study_design_scores_gemma":[0.0005868573,0.008317963,0.0242401,0.0000166915,0.0001046446,0.002759574,0.00004093497,0.001019588,0.9540496,0.0001285996,0.008711063,0.00002442635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865318,0.004599922,0.00202974,0.0002027846,0.00001956272,0.00004853265,0.0005706254,0.0002257061,0.005771387],"genre_scores_gemma":[0.9915276,0.003207875,0.002080562,0.000127878,0.00002197234,0.00002606184,0.0006056229,0.00002264612,0.002379659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001988843,"threshold_uncertainty_score":0.004085958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02484455289644466,"score_gpt":0.274657671377628,"score_spread":0.2498131184811833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}