{"id":"W2051882822","doi":"10.1016/j.mvr.2014.09.008","title":"Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells","year":2014,"lang":"en","type":"article","venue":"Microvascular Research","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Mid-Atlantic Nutrition Obesity Research Center, School of Medicine, University of Maryland; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Nutrition Obesity Research Center, University of North Carolina; National Cancer Institute; National Institutes of Health; Eisai Canada; American Heart Association; Eisai; Australian Historical Association; U.S. Department of Veterans Affairs","keywords":"MSRA; Methionine sulfoxide reductase; Oxidative stress; Biochemistry; Transcription factor; Biology; DNA-binding domain; Chemistry; Cell biology; Methionine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001100968,0.0001588863,0.0001864637,0.000171445,0.0001644748,0.00006846272,0.0001545204,0.0001642543,0.00001549816],"category_scores_gemma":[0.00006411084,0.0001540339,0.00005717045,0.0001627439,0.0002127872,0.00001059967,0.0002741446,0.0002049935,0.00001705965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002536535,"about_ca_system_score_gemma":0.00008283302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001728039,"about_ca_topic_score_gemma":0.00015056,"domain_scores_codex":[0.998113,0.0002920944,0.0001825469,0.0005672676,0.0002302461,0.0006148343],"domain_scores_gemma":[0.9991949,0.0000215566,0.00002716266,0.000484412,0.00007149005,0.0002005339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000988918,0.00005089462,0.001786155,0.0000362835,0.00005539746,0.00001198889,0.0001246618,0.000003540483,0.9866894,0.00004192608,0.0001129427,0.01098786],"study_design_scores_gemma":[0.001256101,0.0002360862,0.001827533,0.00001916167,0.00001100146,0.00002913041,0.00009759471,0.0000504636,0.9230527,0.00007832149,0.07314971,0.0001921509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970909,0.002284356,0.00002684811,0.00003209301,0.00003700674,0.0002205695,0.000007039693,0.000008801904,0.0002923479],"genre_scores_gemma":[0.9972845,0.001118798,0.0006988945,0.0000232565,0.0002489705,0.00001380743,0.0001158998,0.00003920704,0.0004567204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07303677,"threshold_uncertainty_score":0.6281322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611194081561362,"score_gpt":0.2977566403380391,"score_spread":0.2816446995224254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}