{"id":"W2051882822","doi":"10.1016/j.mvr.2014.09.008","title":"Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells","year":2014,"lang":"en","type":"article","venue":"Microvascular Research","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Mid-Atlantic Nutrition Obesity Research Center, School of Medicine, University of Maryland; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Nutrition Obesity Research Center, University of North Carolina; National Cancer Institute; National Institutes of Health; Eisai Canada; American Heart Association; Eisai; Australian Historical Association; U.S. Department of Veterans Affairs","keywords":"MSRA; Methionine sulfoxide reductase; Oxidative stress; Biochemistry; Transcription factor; Biology; DNA-binding domain; Chemistry; Cell biology; Methionine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002450097,0.0002534566,0.0002423654,0.0003337529,0.0003060615,0.0006029403,0.0002298556,0.0002613241,0.002331926],"category_scores_gemma":[0.0002081199,0.0003180347,0.000332211,0.0003401727,0.0003591856,0.0003156189,0.0002644241,0.0005329608,0.0002981011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004027424,"about_ca_system_score_gemma":0.0002564838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001984553,"about_ca_topic_score_gemma":0.002943903,"domain_scores_codex":[0.9997868,0.00003626343,0.00001404382,0.00004641075,0.00004889086,0.00006764739],"domain_scores_gemma":[0.9998924,0.00001738311,0.00002734129,0.00001441842,0.00001371615,0.00003477533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001264896,0.00007748812,0.001626492,0.00002178153,0.00001602921,0.00005399559,0.00007117691,0.00006002065,0.9950802,0.0003561623,0.0001058278,0.001265935],"study_design_scores_gemma":[0.0001002002,0.0003391918,0.04654445,0.000006937794,0.00006721575,0.000223719,0.000399811,0.001294116,0.9472218,0.0003501612,0.003433719,0.00001866329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953917,0.001357422,0.001482192,0.0001687231,0.00005701342,0.00000964986,0.0003603865,0.00004237266,0.001130589],"genre_scores_gemma":[0.9945911,0.000447282,0.0006397689,0.00005804441,0.00002350179,0.00002231835,0.0003954259,0.00002024716,0.00380231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002331926,"threshold_uncertainty_score":0.007800996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611194081561362,"score_gpt":0.2977566403380391,"score_spread":0.2816446995224254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}