{"id":"W2051890221","doi":"10.1016/j.celrep.2015.03.005","title":"The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"National Health and Medical Research Council; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Agence Nationale de la Recherche; General Secretariat for Research and Technology; Fondation ARC pour la Recherche sur le Cancer; Institut National Du Cancer; Human Frontier Science Program; European Molecular Biology Organization; Fondation pour la Recherche Médicale; Centre National de la Recherche Scientifique; Schlumberger Foundation","keywords":"Chromatin; Heterochromatin; DNA damage; Cell biology; DNA repair; Biology; Histone; DNA; Homologous recombination; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009241523,0.0003352402,0.0001898663,0.0002422144,0.0002295503,0.0004932873,0.0003287325,0.0001953194,0.001242775],"category_scores_gemma":[0.0001568562,0.0002360307,0.0002234534,0.0001581751,0.0003744132,0.0002964423,0.0005576892,0.0004481893,0.0004136547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004352862,"about_ca_system_score_gemma":0.0001311598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003151324,"about_ca_topic_score_gemma":0.0005120314,"domain_scores_codex":[0.9998616,0.0000184522,0.000009173944,0.00004189379,0.00003985117,0.00002903783],"domain_scores_gemma":[0.999866,0.00002024448,0.00005187918,0.00001398003,0.0000112832,0.00003663185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004014828,0.000006087617,0.0001757866,0.00001367779,0.000002474836,0.00002971626,0.00001226933,0.0000379498,0.9989141,0.000113597,0.0000159162,0.00063822],"study_design_scores_gemma":[0.000007403802,0.00007562775,0.007491808,0.00000400911,0.000009793152,0.0002723821,0.00003390123,0.001240365,0.9894603,0.0001093506,0.00128886,0.00000616088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893194,0.002475125,0.005499744,0.0000863168,0.00002368843,0.00001231544,0.0001719459,0.0001855156,0.002225918],"genre_scores_gemma":[0.9966195,0.0005070214,0.001203819,0.00001685379,0.000004981804,0.00001179181,0.0001744423,0.00002048641,0.001441122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242775,"threshold_uncertainty_score":0.004157543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016584349313556,"score_gpt":0.2256302234648437,"score_spread":0.2154643799717081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}