{"id":"W2051921450","doi":"10.1038/nm.3855","title":"Functionally defined therapeutic targets in diffuse intrinsic pontine glioma","year":2015,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":711,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health; Johns Hopkins University; Cure Starts Now Foundation; University of Warwick; Northwestern University; U.S. Department of Defense; Oregon Health and Science University; Reflections of Grace Foundation; National Science Foundation; Virginia and D.K. Ludwig Fund for Cancer Research; Alex's Lemonade Stand Foundation for Childhood Cancer; CureSearch for Children's Cancer","keywords":"Panobinostat; Cancer research; Demethylase; Glioma; Histone deacetylase; Histone deacetylase inhibitor; Medicine; Histone; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02011912967613022,"score_gpt":0.2839518861763765,"score_spread":0.2638327565002463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."},"direct_labels":[],"classifier":{"requested":true,"available":true,"version":"metacan-v1-d91a1de5be90","frame_rows_covered":4299418,"decision_targets":["metaresearch","metaepi_narrow","metaepi_broad","bibliometrics","sts","scholarly_communication","open_science","research_integrity","randomized_trial","nonrandomized_trial","observational","systematic_review","meta_analysis","case_report","qualitative","simulation_or_modeling","bench_or_experimental","theoretical_or_conceptual","not_applicable"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame.","warning":null},"prediction":{"classifier_version":"metacan-v1-d91a1de5be90","candidate_union":["observational","bench_or_experimental","theoretical_or_conceptual","not_applicable"],"consensus_intersection":[],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"scores":{"codex":{"metaresearch":0.0003662165255207141,"metaepi_narrow":0.00009155413138017853,"metaepi_broad":0.000030518043793392844,"bibliometrics":0.005920500495918211,"sts":0,"scholarly_communication":0.000045777065690089265,"open_science":0.00039673456931410697,"research_integrity":0.00025940337224383917,"randomized_trial":0.0002136263065537499,"nonrandomized_trial":0.0006561379415579462,"observational":0.010437170977340352,"systematic_review":0.000015259021896696422,"meta_analysis":0.00009155413138017853,"case_report":0.0015106431677729458,"qualitative":0.00009155413138017853,"simulation_or_modeling":0.0003356984817273213,"bench_or_experimental":0.03375295643549248,"theoretical_or_conceptual":0.027359426260776684,"not_applicable":0.0063477531090257115,"design_other":0.05333028152895399},"gemma":{"metaresearch":0.00030518043793392844,"metaepi_narrow":0.00007629510948348211,"metaepi_broad":0.000030518043793392844,"bibliometrics":0.001373311970702678,"sts":0.000015259021896696422,"scholarly_communication":0.00010681315327687495,"open_science":0.00006103608758678569,"research_integrity":0.0001373311970702678,"randomized_trial":0.009643701838712139,"nonrandomized_trial":0.000045777065690089265,"observational":0.200503547722591,"systematic_review":0.000015259021896696422,"meta_analysis":0.00007629510948348211,"case_report":0.0005645838101777677,"qualitative":0.00006103608758678569,"simulation_or_modeling":0.00016784924086366064,"bench_or_experimental":0.05563439383535515,"theoretical_or_conceptual":0.009231708247501335,"not_applicable":0.12356755931944763}},"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame."}}