{"id":"W2051933081","doi":"10.1016/j.bpj.2012.09.020","title":"Tuning of CFTR Chloride Channel Function by Location of Positive Charges within the Pore","year":2012,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Conductance; Chemistry; Divalent; Charge (physics); Chloride channel; Ion; Biophysics; Cystic fibrosis transmembrane conductance regulator; Membrane; Fixed charge; Crystallography; Chemical physics; Condensed matter physics; Physics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003126958,0.00008144456,0.000192557,0.0000539522,0.00007549435,0.000008528172,0.00007652152,0.0000333941,0.00001654598],"category_scores_gemma":[0.0003141624,0.00004861116,0.00006735027,0.0002646759,0.0001607352,0.0001980549,0.00002494793,0.0002690918,0.000006546372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004642234,"about_ca_system_score_gemma":0.00007155072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001870506,"about_ca_topic_score_gemma":2.56115e-7,"domain_scores_codex":[0.9989686,0.00005183428,0.0002474586,0.00007181193,0.0004674177,0.0001928566],"domain_scores_gemma":[0.998979,0.000111396,0.0002432463,0.0001093498,0.0004135262,0.0001435053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007522344,0.0002349812,0.0004937737,0.00006154663,0.00007553647,0.000001311643,0.0004773554,0.00001165054,0.9955238,0.0006800952,0.0004905877,0.001197148],"study_design_scores_gemma":[0.0007479842,0.001064681,0.05232141,0.0004382532,0.0001082337,0.0001208842,0.001090398,0.001051242,0.9425421,0.0002281722,0.0002034428,0.00008316267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880366,0.0006579933,0.009128696,0.001536485,0.000286546,0.0001841363,0.00001374087,0.000008919449,0.0001468753],"genre_scores_gemma":[0.9988853,0.00002485853,0.000190039,0.00006777755,0.0007137746,0.000003688162,0.00001484086,0.00001015853,0.00008952509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05298164,"threshold_uncertainty_score":0.1982305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678073364538627,"score_gpt":0.2879700230139831,"score_spread":0.2711892893685968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}