{"id":"W2051959338","doi":"10.1038/ng1905","title":"Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism","year":2006,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":1198,"is_retracted":false,"has_abstract":false,"ca_institutions":"Shriners Hospitals for Children - Canada; McGill University; Children's Hospital of Eastern Ontario","funders":"National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"DMP1; PHEX; Hypophosphatemic Rickets; Osteocyte; Rickets; Fibroblast growth factor 23; Osteomalacia; Hypophosphatemia; Biology; Endocrinology; Bone remodeling; Internal medicine; Osteoblast; Osteosclerosis; Osteoclast; Genetics; Pathology; Gene; Medicine; Calcium; Vitamin D and neurology; Parathyroid hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974928,0.0006234549,0.0004704832,0.001155632,0.0002567669,0.0004464179,0.0005190426,0.0008254286,0.002252714],"category_scores_gemma":[0.0005238568,0.0004294467,0.000322308,0.0004784482,0.0006804149,0.0002919184,0.000612674,0.0009473794,0.0004167781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002929003,"about_ca_system_score_gemma":0.0002084754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005908641,"about_ca_topic_score_gemma":0.0005356146,"domain_scores_codex":[0.9997945,0.00002535999,0.00002036017,0.00005061601,0.00007805364,0.00003108243],"domain_scores_gemma":[0.9997043,0.0001043632,0.00008509499,0.00002810833,0.00001975752,0.00005837599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008323751,0.00003572927,0.008704884,0.0001033144,0.0000560092,0.006408744,0.00005527881,0.0003370791,0.9729671,0.001029448,0.0004633455,0.00900675],"study_design_scores_gemma":[0.0001576153,0.0002485927,0.08304953,0.00003078122,0.0001471587,0.05554552,0.0002030885,0.002308592,0.8448575,0.001753331,0.01166407,0.00003421475],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821216,0.005145173,0.008019523,0.0007851013,0.00009385913,0.00002778625,0.001082898,0.000161128,0.002562871],"genre_scores_gemma":[0.9926136,0.001479779,0.003434907,0.0001309945,0.00003098138,0.0000263124,0.00053601,0.00004540365,0.001702061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002252714,"threshold_uncertainty_score":0.007536113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006080020615354734,"score_gpt":0.2648821096731568,"score_spread":0.2588020890578021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}