{"id":"W2052021935","doi":"10.1159/000333339","title":"Preplaque (‘Preclinical’) Aβ-Induced Inflammation and Nerve Growth Factor Deregulation in Transgenic Models of Alzheimer’s Disease-Like Amyloid Pathology","year":2012,"lang":"en","type":"article","venue":"Neurodegenerative Diseases","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Alzheimer Society; McGill University","keywords":"Microglia; Neuropathology; Pathology; Genetically modified mouse; Proinflammatory cytokine; Neurodegeneration; Inflammation; Amyloid (mycology); Hippocampal formation; Neurochemical; Nerve growth factor; Amyloid precursor protein; Neuroscience; Transgene; Alzheimer's disease; Medicine; Biology; Disease; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001089962,0.0003084373,0.0004935066,0.0002336395,0.00008636203,0.00001852155,0.00007601182,0.0001061935,0.00005938432],"category_scores_gemma":[0.0001873952,0.0002650132,0.0001908465,0.0002321443,0.0001617571,0.0006404578,0.00005290786,0.0001659103,0.00000847657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004442961,"about_ca_system_score_gemma":0.0002532545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003761949,"about_ca_topic_score_gemma":0.00001576363,"domain_scores_codex":[0.9975941,0.0004735254,0.0005398012,0.0005017305,0.0004257766,0.000465034],"domain_scores_gemma":[0.9982348,0.0001817458,0.0001628407,0.0003602058,0.0002152026,0.000845224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003220748,0.002731412,0.9580756,0.0002961684,0.001968856,0.0001536939,0.00101746,0.0002596028,0.02575281,0.001680163,0.00007094165,0.004772476],"study_design_scores_gemma":[0.002646715,0.0003634859,0.9559534,0.00006947622,0.001048536,0.000008557419,0.00004207133,0.002647087,0.03628906,0.0007062625,0.00000304987,0.0002222692],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865282,0.0113271,0.0001094371,0.0002770358,0.00009127286,0.001191028,0.0003577466,0.00005116906,0.00006707853],"genre_scores_gemma":[0.9985551,0.0004229503,0.0001149729,0.0000887266,0.0001592114,0.0002122771,0.00039658,0.00004318826,0.000006995977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01202697,"threshold_uncertainty_score":0.9999802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08284423286966769,"score_gpt":0.3416946662587775,"score_spread":0.2588504333891098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}