{"id":"W2052021935","doi":"10.1159/000333339","title":"Preplaque (‘Preclinical’) Aβ-Induced Inflammation and Nerve Growth Factor Deregulation in Transgenic Models of Alzheimer’s Disease-Like Amyloid Pathology","year":2012,"lang":"en","type":"article","venue":"Neurodegenerative Diseases","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Alzheimer Society; McGill University","keywords":"Microglia; Neuropathology; Pathology; Genetically modified mouse; Proinflammatory cytokine; Neurodegeneration; Inflammation; Amyloid (mycology); Hippocampal formation; Neurochemical; Nerve growth factor; Amyloid precursor protein; Neuroscience; Transgene; Alzheimer's disease; Medicine; Biology; Disease; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004743198,0.001252573,0.000576562,0.001110251,0.0003896932,0.0005627056,0.0004673189,0.0008670676,0.002117912],"category_scores_gemma":[0.0002351968,0.0004025288,0.0007049651,0.00049519,0.0007448494,0.0007557437,0.0004125381,0.0015894,0.001011837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006471382,"about_ca_system_score_gemma":0.0003879276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007380599,"about_ca_topic_score_gemma":0.001177843,"domain_scores_codex":[0.9996293,0.00004640158,0.00005845405,0.0001035613,0.00008085721,0.00008130074],"domain_scores_gemma":[0.9994208,0.00004878345,0.0002530224,0.00006879097,0.0000685518,0.0001400977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000762428,0.0004277415,0.0003309819,0.00007419131,0.0000119966,0.0001993479,0.00006196385,0.00004615566,0.9971278,0.00009004655,0.00006874418,0.0007985584],"study_design_scores_gemma":[0.0002056929,0.006871036,0.01591749,0.00005300936,0.0001363291,0.001822773,0.00014867,0.0006732414,0.9702785,0.0004375566,0.003422199,0.00003345724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899371,0.001913913,0.004764543,0.0001343237,0.00008827271,0.0002040073,0.001114897,0.000300361,0.00154266],"genre_scores_gemma":[0.9822927,0.002597222,0.007248738,0.0001624133,0.0000581054,0.0006875627,0.002574499,0.000147404,0.004231362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002117912,"threshold_uncertainty_score":0.007085085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08284423286966769,"score_gpt":0.3416946662587775,"score_spread":0.2588504333891098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}