{"id":"W2052024751","doi":"10.1038/sj.onc.1204289","title":"Over-representation of a germline variant in the gene encoding RET co-receptor GFRα-1 but not GFRα-2 or GFRα-3 in cases with sporadic medullary thyroid carcinoma","year":2001,"lang":"en","type":"article","venue":"Oncogene","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute","keywords":"Biology; Proto-Oncogene Proteins c-ret; Germline mutation; Germline; Thyroid carcinoma; Immunostaining; Somatic cell; Allele; Genetics; Molecular biology; Cancer research; Gene; Mutation; Thyroid; Receptor; Immunohistochemistry; Glial cell line-derived neurotrophic factor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003880463,0.0003080105,0.0006636876,0.000274445,0.00006456691,0.00002184749,0.000180366,0.000117674,0.000400682],"category_scores_gemma":[0.0001070259,0.0001921543,0.0001149943,0.0008233368,0.0001056824,0.000118119,0.00003704536,0.0002127034,0.00001878884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003856803,"about_ca_system_score_gemma":0.0003682564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005899133,"about_ca_topic_score_gemma":0.003620455,"domain_scores_codex":[0.997686,0.0001606382,0.0006198638,0.0005102055,0.0006094416,0.0004138926],"domain_scores_gemma":[0.9985517,0.0003534418,0.0002593526,0.0006017357,0.00009855323,0.0001351778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009488422,0.00346819,0.6562835,0.0001687649,0.0003270381,0.02896006,0.004311115,0.0003072796,0.2838236,0.0001144922,0.004873189,0.007874367],"study_design_scores_gemma":[0.0243587,0.006732684,0.5656548,0.0008032289,0.000667344,0.006486977,0.0036051,0.000457765,0.3867307,0.00003744191,0.00373573,0.0007295244],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993852,0.002363349,0.00002739018,0.001841746,0.0001217501,0.0009922044,0.0001756978,0.00002491198,0.0006009584],"genre_scores_gemma":[0.9951973,0.002190538,0.0006527203,0.0008127671,0.000306437,0.0002129282,0.0003496099,0.00004412012,0.0002335848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1029071,"threshold_uncertainty_score":0.8917763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04385182848005889,"score_gpt":0.3197395220014861,"score_spread":0.2758876935214273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}