{"id":"W2052027458","doi":"10.1158/1535-7163.targ-11-b220","title":"Abstract B220: Artificially inducing protein-membrane anchorage: Introducing a new therapeutic modality.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cell biology; Cancer cell; STAT3; Prenylation; STAT protein; Membrane protein; Gene knockdown; Target protein; Chemistry; Biology; Biochemistry; Cancer; Membrane; Signal transduction; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123966,0.0003061683,0.0001273057,0.0001831642,0.00009656153,0.0002175189,0.0001749304,0.0003836581,0.0009432507],"category_scores_gemma":[0.00008370115,0.000112109,0.0001970691,0.000122422,0.0001936366,0.0002488571,0.0001905939,0.0005991651,0.0003754268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254202,"about_ca_system_score_gemma":0.0001507973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001956383,"about_ca_topic_score_gemma":0.0001955031,"domain_scores_codex":[0.9999317,0.00001649175,0.000004844175,0.00001553107,0.00001889527,0.00001247743],"domain_scores_gemma":[0.9999552,0.000008480759,0.00001644502,0.000004462078,0.000004247322,0.00001112935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000545508,0.00002572913,0.00004148554,0.0000380557,0.000002643688,0.0000309801,0.000005761809,0.00006181864,0.9978352,0.0002774798,0.0000577022,0.001568603],"study_design_scores_gemma":[0.00001614982,0.0002655187,0.0002886621,0.000003888657,0.000008790124,0.0001853868,0.000004925883,0.0003748712,0.9937088,0.00006039213,0.005078844,0.000003703536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450893,0.00705478,0.0393931,0.0007958202,0.0002601174,0.0002613128,0.0008190215,0.000400254,0.005926172],"genre_scores_gemma":[0.9793585,0.002081263,0.01473255,0.0001574165,0.00002270388,0.00008176893,0.000375477,0.0000261175,0.003164315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009432507,"threshold_uncertainty_score":0.00315547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05590477500370283,"score_gpt":0.2895475400700889,"score_spread":0.2336427650663861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}