{"id":"W2052032402","doi":"10.4161/chan.5391","title":"Reversed Na<sup>+</sup>/Ca<sup>2+</sup>Exchange Contributes to Ca<sup>2+</sup>Influx and Respiratory Burst in Microglia","year":2007,"lang":"en","type":"article","venue":"Channels","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute for Health and Care Research; Heart and Stroke Foundation of Canada","keywords":"Sodium-calcium exchanger; Phagocytosis; Chemistry; Extracellular; Biophysics; Microglia; Intracellular; Calcium; Fura-2; Molecular biology; Biochemistry; Cell biology; Biology; Cytosol; Enzyme; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001816752,0.0008976034,0.0009167299,0.001261301,0.0006673071,0.0004311968,0.0008626433,0.0004722794,0.0005505426],"category_scores_gemma":[0.001955535,0.0009549723,0.0002256226,0.001659338,0.0002809529,0.0008131626,0.0004513599,0.0008266916,0.001209843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002713415,"about_ca_system_score_gemma":0.0001736108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006309964,"about_ca_topic_score_gemma":0.00003162304,"domain_scores_codex":[0.9933543,0.0006809304,0.001416007,0.001964461,0.0009431491,0.001641187],"domain_scores_gemma":[0.9966837,0.0007634678,0.0003204481,0.001119694,0.0002870565,0.0008256669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007914023,0.0004371019,0.0003948734,0.0002998108,0.00003592464,0.001202862,0.01374277,0.05040677,0.8918724,0.003125695,0.03501294,0.002677437],"study_design_scores_gemma":[0.004133658,0.0005451262,0.0001542282,0.0001956467,0.00004491524,0.0001045103,0.001450287,0.05821842,0.825307,0.0004750636,0.1081583,0.001212817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990293,0.0002970459,0.0017251,0.003296916,0.0006745163,0.002174711,0.0003279547,0.0003970742,0.0008136616],"genre_scores_gemma":[0.9607188,0.0001538017,0.000262993,0.03245207,0.0008682641,0.0002131577,0.00005174788,0.0001944027,0.005084763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07314537,"threshold_uncertainty_score":0.9995678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03707797146684738,"score_gpt":0.2728969097469975,"score_spread":0.2358189382801502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}