{"id":"W2052034341","doi":"10.1038/ncomms7410","title":"Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario; McGill University; Ottawa Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Oncolytic virus; Bystander effect; Vaccinia; Cancer cell; Microtubule; Virotherapy; Translation (biology); Biology; Cancer; Microtubule polymerization; Cancer research; Interferon; Virology; Cell biology; Immunology; Virus; Messenger RNA; Gene; Genetics; Tubulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009277424,0.0003778653,0.0002660027,0.0002500356,0.000169303,0.0002859219,0.000142727,0.0002501722,0.001286154],"category_scores_gemma":[0.00008109227,0.0000859986,0.0001990425,0.00009612312,0.0001849917,0.0002259125,0.0001622762,0.0004760065,0.0002941136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002578822,"about_ca_system_score_gemma":0.0001972756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002634201,"about_ca_topic_score_gemma":0.0008703633,"domain_scores_codex":[0.9999195,0.00001748571,0.000006959865,0.00001507133,0.00001933554,0.00002170378],"domain_scores_gemma":[0.9999423,0.00001585872,0.00001584554,0.000008973991,0.000005085855,0.00001192471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002285099,0.00009153999,0.0001338224,0.00005637023,0.00001133461,0.00005635368,0.00001905024,0.0003407449,0.9928428,0.0002155697,0.0001068696,0.005896929],"study_design_scores_gemma":[0.00003997468,0.001030323,0.001460269,0.000005442997,0.00001920259,0.0001769106,0.00001088262,0.0006719679,0.9928775,0.00008509774,0.003617699,0.000004659328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867863,0.004231331,0.003815754,0.0002187294,0.00009973226,0.00007783522,0.0001351128,0.0001630831,0.004472044],"genre_scores_gemma":[0.9952198,0.001602675,0.001408025,0.00003792429,0.0000338904,0.00003099136,0.00009879635,0.00001751655,0.001550377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286154,"threshold_uncertainty_score":0.004302621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02924404615216132,"score_gpt":0.3249140447641661,"score_spread":0.2956699986120048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}