{"id":"W2052034341","doi":"10.1038/ncomms7410","title":"Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario; McGill University; Ottawa Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Oncolytic virus; Bystander effect; Vaccinia; Cancer cell; Microtubule; Virotherapy; Translation (biology); Biology; Cancer; Microtubule polymerization; Cancer research; Interferon; Virology; Cell biology; Immunology; Virus; Messenger RNA; Gene; Genetics; Tubulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003513608,0.0001219191,0.00009827771,0.00004882515,0.0002152907,0.00005655293,0.0002698075,0.0001929525,0.000003199045],"category_scores_gemma":[0.00003101932,0.0001095766,0.00002800815,0.0001240193,0.0001172331,0.00001432324,0.0000795853,0.0003681954,0.000001433492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003823485,"about_ca_system_score_gemma":0.00006622301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001622805,"about_ca_topic_score_gemma":0.0007763996,"domain_scores_codex":[0.9991518,0.0001700322,0.0001572281,0.0002130917,0.0001465711,0.0001612931],"domain_scores_gemma":[0.9991616,0.00003887579,0.00007481621,0.0005068087,0.0001391052,0.00007881819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005362335,0.00006286181,0.0005881437,0.000007825804,0.00004966703,2.349355e-7,0.0003544006,0.00005978017,0.9846797,0.0000240208,0.0004497236,0.01318739],"study_design_scores_gemma":[0.004943752,0.004542104,0.0002978897,0.0002249969,0.00007561708,0.00005076646,0.00215222,0.009469978,0.9395851,0.000145269,0.03771279,0.0007995548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615296,0.03191341,0.004200255,0.001510127,0.00002458483,0.0003250121,0.00002059133,0.00002660323,0.0004498072],"genre_scores_gemma":[0.9940983,0.001261218,0.003895755,0.0002122088,0.00004714301,0.00004096407,0.0003320357,0.00003077133,0.00008160633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04509465,"threshold_uncertainty_score":0.4468403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02924404615216132,"score_gpt":0.3249140447641661,"score_spread":0.2956699986120048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}