{"id":"W2052042350","doi":"10.1093/toxsci/kfm177","title":"The Dynamic Epigenome and its Implications in Toxicology","year":2007,"lang":"en","type":"review","venue":"Toxicological Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Epigenome; Epigenetics; DNA methylation; Biology; Genetics; Chromatin; Epigenomics; Xenobiotic; Epigenesis; Computational biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001340661,0.0001907417,0.0003594108,0.0000754022,0.0003492994,0.00005798415,0.0004751493,0.0004344397,0.00001195934],"category_scores_gemma":[0.0003108714,0.0001084271,0.00009639139,0.0003626489,0.0004366314,0.000002466628,0.0002361029,0.0001778191,0.00001087057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003581866,"about_ca_system_score_gemma":0.0001487923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002026355,"about_ca_topic_score_gemma":0.0002037086,"domain_scores_codex":[0.9983991,0.0002029261,0.0003911314,0.0005119786,0.0001041241,0.0003907034],"domain_scores_gemma":[0.9992471,0.0002985812,0.0001620027,0.0001819596,0.00002690677,0.00008344315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002447498,0.00003919075,0.00007178796,0.00008806544,0.00000953013,0.000001445942,0.000004574497,0.000004887312,0.001521283,0.002587133,0.00001020086,0.9956595],"study_design_scores_gemma":[0.00004886759,0.0003631391,0.001379175,0.00005646423,0.00001961045,0.000006060187,0.000007845828,0.00001156534,0.00006167465,0.001034417,0.9968323,0.0001789517],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007754624,0.9894943,0.00005811621,0.0001772945,0.0001074197,0.0004814164,0.00001010756,0.000006614384,0.001910151],"genre_scores_gemma":[0.007454152,0.991813,0.0001214915,0.00005591317,0.00006290847,0.00009203944,0.00002038178,0.000007561929,0.0003725297],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.996822,"threshold_uncertainty_score":0.4421527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1074675808670695,"score_gpt":0.4234402536262942,"score_spread":0.3159726727592247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}