{"id":"W2052042350","doi":"10.1093/toxsci/kfm177","title":"The Dynamic Epigenome and its Implications in Toxicology","year":2007,"lang":"en","type":"review","venue":"Toxicological Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Epigenome; Epigenetics; DNA methylation; Biology; Genetics; Chromatin; Epigenomics; Xenobiotic; Epigenesis; Computational biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008566603,0.00107368,0.001542046,0.002084127,0.0005362199,0.001334919,0.001253946,0.002364209,0.002391979],"category_scores_gemma":[0.0009450174,0.0003168559,0.0004247854,0.002071147,0.002318639,0.002752097,0.0009567696,0.002313969,0.00151819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001523489,"about_ca_system_score_gemma":0.00133497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591152,"about_ca_topic_score_gemma":0.002428768,"domain_scores_codex":[0.9997339,0.00007332632,0.00002987921,0.00004724299,0.00009417683,0.00002152535],"domain_scores_gemma":[0.9994757,0.0002906068,0.00004166227,0.000022288,0.000119081,0.00005069541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006656206,0.00005565437,0.0003450717,0.009587306,0.00006988497,0.0007275686,0.0002460284,0.0007514581,0.003057545,0.02874929,0.04076308,0.9155805],"study_design_scores_gemma":[0.00001036516,0.00006726171,0.00103006,0.001990891,0.00003798142,0.003042956,0.0001706118,0.0001404533,0.0006187457,0.02234502,0.9705161,0.00002956913],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000760492,0.9975843,0.000265723,0.0007918862,0.0003232956,0.000002478651,0.000005584166,0.000005954975,0.0009446833],"genre_scores_gemma":[0.0008288612,0.9976175,0.0002127928,0.00032849,0.0003054669,0.000005004062,0.000008459561,0.000001085144,0.0006922829],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002391979,"threshold_uncertainty_score":0.0110538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1074675808670695,"score_gpt":0.4234402536262942,"score_spread":0.3159726727592247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}