{"id":"W2052048865","doi":"10.1016/j.canlet.2014.01.018","title":"The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator","year":2014,"lang":"en","type":"review","venue":"Cancer Letters","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":356,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"AMPK; Regulator; Protein kinase A; AMP-activated protein kinase; Cell biology; Cancer cell; Context (archaeology); Biology; Autophagy; Cancer research; Cell growth; Cancer; Kinase; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002457328,0.0004849458,0.001244658,0.00006268501,0.0001280725,0.00005112679,0.0004515524,0.0002784206,0.00004461041],"category_scores_gemma":[0.00004261712,0.0003280642,0.0003391598,0.0001805654,0.0003485678,0.000005552788,0.0001302536,0.0002306865,0.000004231929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003203984,"about_ca_system_score_gemma":0.0002928925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001964769,"about_ca_topic_score_gemma":0.00009440013,"domain_scores_codex":[0.9980091,0.0002347077,0.0005028998,0.0006106311,0.0002099167,0.0004327557],"domain_scores_gemma":[0.9984552,0.00002511629,0.0006014791,0.0007155893,0.00008005964,0.0001225975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002201954,0.00000819426,0.00000940571,0.003084922,0.0004889748,4.966941e-7,0.00002034618,0.000002476231,0.01778925,0.00006844779,0.005917768,0.9725877],"study_design_scores_gemma":[0.0002608032,0.00001792749,0.00001348916,0.001639805,0.0004854228,0.000001548788,0.000003634531,4.863385e-7,0.01605435,0.000004996628,0.981137,0.0003805567],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01257323,0.9856209,0.00002536634,0.0001293578,0.000476643,0.0009103356,0.0002228121,0.00001113833,0.00003022077],"genre_scores_gemma":[0.0001791076,0.9961237,0.00004225008,0.000616541,0.000905472,0.00145933,0.00007556324,0.00007669705,0.0005213111],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9752192,"threshold_uncertainty_score":0.9999171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958348701073399,"score_gpt":0.3016028531792662,"score_spread":0.2820193661685322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}