{"id":"W2052078379","doi":"10.1371/journal.pbio.1000573","title":"The In Vivo Kinetics of RNA Polymerase II Elongation during Co-Transcriptional Splicing","year":2011,"lang":"en","type":"article","venue":"PLoS Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Advanced Science Institute; Agence Nationale de la Recherche; RIKEN; Azrieli Foundation; University of Pittsburgh","keywords":"RNA polymerase II; RNA splicing; Biology; Intron; Spliceosome; snRNP; Transcription (linguistics); Polyadenylation; RNA polymerase II holoenzyme; Small nuclear RNA; Chromatin; Exon; Precursor mRNA; Molecular biology; Exonic splicing enhancer; Cell biology; Gene; RNA polymerase; Polymerase; RNA; Genetics; Gene expression; RNA-dependent RNA polymerase; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125206,0.00008260035,0.00009979379,0.00005177981,0.00009255659,0.000003605794,0.0001705715,0.0001040492,0.00004070324],"category_scores_gemma":[0.00007465792,0.00006261541,0.00004318176,0.00006398874,0.0001406333,0.000002562892,0.00005655897,0.00007134725,0.000002116611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001067951,"about_ca_system_score_gemma":0.00002372612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001263274,"about_ca_topic_score_gemma":0.0001878089,"domain_scores_codex":[0.9992203,0.00007486015,0.0002101139,0.0001778216,0.00006651765,0.0002503525],"domain_scores_gemma":[0.9996465,0.00001850582,0.00005810244,0.0001865666,0.00004730407,0.00004295111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001704751,0.00007626748,0.01287376,0.00001040856,0.00002658912,0.000001410178,0.00008797587,0.000002570292,0.9858431,0.0005288926,0.00001755203,0.0003609716],"study_design_scores_gemma":[0.0003666632,0.0003125409,0.0181983,0.0000105449,0.000003713644,0.000004435396,0.00005198363,0.00005082076,0.9805381,0.0001059322,0.0002881728,0.0000687839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979971,0.0004653225,0.0001243255,0.00008296613,0.00004098164,0.0001131871,0.00001499696,0.000004611831,0.00115649],"genre_scores_gemma":[0.9990135,0.0002708268,0.0001482995,0.00003780063,0.00007450257,0.0000157917,0.0000240999,0.000009152724,0.0004059607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005324544,"threshold_uncertainty_score":0.2553382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02230036555875475,"score_gpt":0.2630165903033162,"score_spread":0.2407162247445614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}