{"id":"W2052078379","doi":"10.1371/journal.pbio.1000573","title":"The In Vivo Kinetics of RNA Polymerase II Elongation during Co-Transcriptional Splicing","year":2011,"lang":"en","type":"article","venue":"PLoS Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Advanced Science Institute; Agence Nationale de la Recherche; RIKEN; Azrieli Foundation; University of Pittsburgh","keywords":"RNA polymerase II; RNA splicing; Biology; Intron; Spliceosome; snRNP; Transcription (linguistics); Polyadenylation; RNA polymerase II holoenzyme; Small nuclear RNA; Chromatin; Exon; Precursor mRNA; Molecular biology; Exonic splicing enhancer; Cell biology; Gene; RNA polymerase; Polymerase; RNA; Genetics; Gene expression; RNA-dependent RNA polymerase; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005529344,0.0003340139,0.0003322861,0.0001951943,0.0001684533,0.0006665104,0.0003204382,0.0002916822,0.0009687584],"category_scores_gemma":[0.0005337549,0.0003476088,0.000251204,0.0002285707,0.0002694899,0.0004002729,0.0001475063,0.0006113627,0.0006391348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004998968,"about_ca_system_score_gemma":0.0001907489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005913628,"about_ca_topic_score_gemma":0.0006563966,"domain_scores_codex":[0.999553,0.00006514916,0.00004095402,0.0001821607,0.0001145398,0.00004408693],"domain_scores_gemma":[0.9996521,0.0001478842,0.00006043746,0.00004796977,0.00005917231,0.00003235012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001492188,0.00001969465,0.0008595198,0.00003112813,0.000006962237,0.00001916145,0.00002548007,0.0002250888,0.9959682,0.0001815361,0.00003094075,0.002482892],"study_design_scores_gemma":[0.000004338725,0.00005702464,0.002324029,0.000002570614,0.000006518964,0.0000475847,0.000008135792,0.002454799,0.9944394,0.0000646098,0.0005861962,0.000004728273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588823,0.002002914,0.03630245,0.00008069523,0.00006795693,0.00003603027,0.0007109953,0.0002011145,0.001715518],"genre_scores_gemma":[0.9865829,0.000967918,0.009700334,0.00002151473,0.00001868346,0.00004769319,0.000834538,0.00006010568,0.001766286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009687584,"threshold_uncertainty_score":0.003627062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02230036555875475,"score_gpt":0.2630165903033162,"score_spread":0.2407162247445614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}