{"id":"W2052085171","doi":"10.1021/jm301176r","title":"Novel Cytidine-Based Orotidine-5′-Monophosphate Decarboxylase Inhibitors with an Unusual Twist","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Ontario Institute for Cancer Research; University of Toronto; Canada Research Chairs; University Health Network","funders":"National Research Council Canada; Canada Research Chairs; Ontario Ministry of Health and Long-Term Care","keywords":"Chemistry; Cytidine; Biochemistry; Twist; Stereochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001454175,0.0004438336,0.0003912314,0.0001067613,0.0001299618,0.0002346523,0.0004573824,0.0003307838,0.0008344396],"category_scores_gemma":[0.0001201827,0.0002125693,0.0002008545,0.0001135084,0.0001921289,0.0002346051,0.0002387356,0.0004965888,0.0003050571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314599,"about_ca_system_score_gemma":0.000169156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004025155,"about_ca_topic_score_gemma":0.0008124057,"domain_scores_codex":[0.9998955,0.00002716446,0.000006758545,0.0000207201,0.0000227177,0.00002711766],"domain_scores_gemma":[0.999935,0.000009031328,0.00001982752,0.000006028067,0.000008518222,0.00002166123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003431978,0.0000972229,0.0001483448,0.0001777818,0.00001886727,0.0001881025,0.00003073962,0.0009171393,0.9863452,0.0007654765,0.0001924944,0.01077555],"study_design_scores_gemma":[0.0001613494,0.001873274,0.0007888753,0.00001427502,0.00003246382,0.0005059892,0.00001129331,0.002480629,0.9823825,0.0001193591,0.01160695,0.00002303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657229,0.005103548,0.01569238,0.0002168529,0.0001072534,0.0002588085,0.0003744014,0.0002364292,0.01228733],"genre_scores_gemma":[0.979839,0.002151063,0.01307607,0.0002204633,0.00002578273,0.0001279812,0.0003245824,0.00002925898,0.004205798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008344396,"threshold_uncertainty_score":0.002791464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277782824011804,"score_gpt":0.2730151939206119,"score_spread":0.2602373656804938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}