{"id":"W2052097013","doi":"10.1089/adt.2014.587","title":"Assays for the Identification and Prioritization of Drug Candidates for Spinal Muscular Atrophy","year":2014,"lang":"en","type":"review","venue":"Assay and Drug Development Technologies","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Portage College","funders":"PTC Therapeutics; Spinal Muscular Atrophy Foundation","keywords":"SMN1; Spinal muscular atrophy; SMA*; Drug discovery; Candidate gene; Exon; Biology; Gene; Bioinformatics; Weakness; Medicine; Genetics; Computational biology; Anatomy; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008777317,0.001283141,0.001895453,0.004193714,0.0002893236,0.0009876126,0.001107036,0.001314986,0.003967665],"category_scores_gemma":[0.001047084,0.0004757164,0.00079432,0.003004094,0.0004811782,0.001228199,0.0006554095,0.0014158,0.003736737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000678776,"about_ca_system_score_gemma":0.0009214981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006759633,"about_ca_topic_score_gemma":0.001304018,"domain_scores_codex":[0.9995783,0.00007223018,0.00004359286,0.00007012951,0.0002041287,0.00003166274],"domain_scores_gemma":[0.9995704,0.0002193974,0.00006143402,0.00001799176,0.0001085734,0.0000221473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007319194,0.0001858504,0.0003059107,0.01575805,0.0001465925,0.0002572035,0.00005230028,0.0007652872,0.0133421,0.00612612,0.01008531,0.952902],"study_design_scores_gemma":[0.00003236648,0.000321433,0.001183633,0.002408134,0.0002524015,0.001496988,0.00006734312,0.0003402964,0.009723125,0.00194403,0.9821814,0.00004897677],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007319824,0.9923895,0.001878713,0.0002228483,0.0001643817,0.00005054852,0.00011544,0.00004537838,0.004401293],"genre_scores_gemma":[0.002995986,0.9917835,0.00270664,0.0001874906,0.00007953629,0.00004890001,0.0001695682,0.000007496543,0.002020806],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004193714,"threshold_uncertainty_score":0.01327318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02973293074908764,"score_gpt":0.337538243274346,"score_spread":0.3078053125252584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}