{"id":"W2052097134","doi":"10.1007/s12015-013-9488-6","title":"Disrupted WNT Signaling in Mouse Embryonic Stem Cells in the Absence of Calreticulin","year":2014,"lang":"en","type":"article","venue":"Stem Cell Reviews and Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; Calreticulin; Cell biology; WNT3A; Endoplasmic reticulum; Biology; LRP6; Stem cell; Embryonic stem cell; Signal transduction; Cellular differentiation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007560494,0.0001328704,0.0002374594,0.00002938426,0.00002652391,0.00001194904,0.00009561127,0.00006609056,0.000002721686],"category_scores_gemma":[0.000007171939,0.00008773342,0.00006136786,0.00009526671,0.00004453113,0.000001755055,0.000060043,0.00007618437,0.000001335088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004440534,"about_ca_system_score_gemma":0.0000244738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001820152,"about_ca_topic_score_gemma":0.00005586074,"domain_scores_codex":[0.9987575,0.0001567994,0.0005137614,0.0003051822,0.000102885,0.0001638791],"domain_scores_gemma":[0.9994351,0.00001434203,0.0002234049,0.0002736641,0.00001710469,0.00003640726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000532798,0.00006219912,0.00500857,0.0002449294,0.000002748371,0.00001818445,0.000218644,0.0001053793,0.9877549,0.000007646256,0.0001002325,0.006471172],"study_design_scores_gemma":[0.0004944648,0.0002794503,0.0119128,0.0002697045,0.00001545289,0.00006542578,0.0005804439,0.00008542062,0.9127123,0.00004322704,0.07311763,0.000423657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867786,0.01218993,0.00003823555,0.00002721181,0.000068363,0.0003994836,0.000001208535,0.000001449247,0.0004954904],"genre_scores_gemma":[0.9898951,0.009438614,0.00006613194,0.0001062015,0.000007258504,0.00002293139,0.000006302946,0.000009823592,0.0004476145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07504264,"threshold_uncertainty_score":0.3577665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126336405946952,"score_gpt":0.2276882171526882,"score_spread":0.2164248530932187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}