{"id":"W2052099280","doi":"10.1006/mgme.2001.3210","title":"Structure of the PCCA Gene and Distribution of Mutations Causing Propionic Acidemia","year":2001,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Gene; Propionic acidemia; Biology; Exon; Start codon; Genetics; Eukaryotic translation; Intron; Stop codon; Nucleotide; Mutation; Molecular biology; Biochemistry; Translation (biology); Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001250444,0.0004876254,0.0003464187,0.001961733,0.0005050643,0.000347636,0.0005388637,0.000583247,0.002872211],"category_scores_gemma":[0.00112817,0.0002689319,0.0002725862,0.0009823201,0.0009262079,0.0002413158,0.0002638172,0.0005298137,0.0004040682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004969368,"about_ca_system_score_gemma":0.0003238984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005257355,"about_ca_topic_score_gemma":0.0014257,"domain_scores_codex":[0.9998135,0.00003239511,0.00002726048,0.0000517105,0.00003604253,0.00003907443],"domain_scores_gemma":[0.999194,0.0004046592,0.000111244,0.00003915553,0.00007599132,0.0001749824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005547347,0.000560794,0.08289107,0.0002442049,0.0001571486,0.03884808,0.001004231,0.002256889,0.8453287,0.004364052,0.0009529234,0.01784454],"study_design_scores_gemma":[0.0005556095,0.001336873,0.6811137,0.0001204659,0.0005335683,0.08547036,0.00113762,0.007688878,0.2091541,0.00488457,0.007883324,0.0001210137],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958196,0.0007257713,0.0007622488,0.0001670641,0.00001708948,0.0000201929,0.0004672389,0.00002817441,0.001992519],"genre_scores_gemma":[0.998477,0.0002563363,0.0004697321,0.00002983067,0.00002116903,0.00001262272,0.0002868906,0.000009935504,0.0004363784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005257355,"threshold_uncertainty_score":0.01045352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004404828048877422,"score_gpt":0.2188571920088918,"score_spread":0.2144523639600144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}