{"id":"W2052102717","doi":"10.1096/fj.14-254037","title":"A peptide targeting an interaction interface disrupts the dopamine D1‐D2 receptor heteromer to block signaling and function <i>in vitro</i> and <i>in vivo:</i> effective selective antagonism","year":2014,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; National Institutes of Health","keywords":"Dopamine receptor D2; 5-HT5A receptor; Dopamine receptor D1; Receptor; G protein-coupled receptor; Nuclear receptor co-repressor 1; Chemistry; Pharmacology; Biology; Biochemistry; Nuclear receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001282069,0.0001923168,0.0001826801,0.00007377454,0.0002619958,0.0001334004,0.0001279583,0.00008029063,0.00001165876],"category_scores_gemma":[0.00009660096,0.0001239448,0.0000502488,0.0001124443,0.00004564905,0.00002960681,0.00008647816,0.0004026093,0.000001812458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004275057,"about_ca_system_score_gemma":0.00001463099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004442695,"about_ca_topic_score_gemma":0.00004381804,"domain_scores_codex":[0.9985155,0.0005000758,0.0002708044,0.0003078162,0.0001263454,0.0002794447],"domain_scores_gemma":[0.9994671,0.00009672029,0.0001418229,0.0001277786,0.00006305039,0.0001035746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008806332,0.00003040532,0.0003139358,0.000006014844,0.00002929338,0.000001354205,0.0007111976,0.001364188,0.9926304,0.000002901334,0.00006312782,0.003966576],"study_design_scores_gemma":[0.000634384,0.0007367653,0.0002041155,0.00005822442,0.00002117344,0.0001284729,0.001266024,0.00135805,0.9941051,0.00007085187,0.001251708,0.0001651274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911172,0.0003126174,0.007687068,0.0002007698,0.0003246973,0.0002983685,0.000005438351,0.000006064868,0.0000477181],"genre_scores_gemma":[0.9986539,0.00008354006,0.000359327,0.0003358485,0.0004703946,0.0000230134,0.000006559758,0.00002463109,0.00004275249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007536675,"threshold_uncertainty_score":0.5054324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005415006860134739,"score_gpt":0.2345039376528889,"score_spread":0.2290889307927542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}