{"id":"W2052117565","doi":"10.1172/jci10727","title":"Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes","year":2000,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":318,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Royal Victoria Hospital; Xenon Pharmaceuticals (Canada); McGill University Health Centre; Royal Victoria Regional Health Centre; University of British Columbia","funders":"Medical Research Council; Promotion and Mutual Aid Corporation for Private Schools of Japan; BC Children's Hospital; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Tangier disease; ABCA1; Cholesterol; Heterozygote advantage; Internal medicine; Endocrinology; Efflux; Compound heterozygosity; Familial hypercholesterolemia; Biology; ATP Binding Cassette Transporter 1; Coronary artery disease; Residual risk; Medicine; Genetics; Mutation; Genotype; Gene; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004474617,0.0006387049,0.0004324495,0.001333819,0.0004119459,0.0003831456,0.0001691131,0.0007282791,0.002320232],"category_scores_gemma":[0.002556215,0.0002990829,0.0002512857,0.0003722512,0.0004485007,0.0003074372,0.0002826691,0.000308386,0.0002968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001481431,"about_ca_system_score_gemma":0.00008833264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150701,"about_ca_topic_score_gemma":0.000917352,"domain_scores_codex":[0.9996797,0.00008369986,0.00004136179,0.00007555352,0.00005058598,0.00006923891],"domain_scores_gemma":[0.9993943,0.0002077575,0.0001766203,0.00003613833,0.00004161373,0.0001436003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004646147,0.0004854323,0.9014419,0.00006528151,0.0001813635,0.017968,0.0007175719,0.0001593474,0.056319,0.0003756165,0.0004680391,0.01717236],"study_design_scores_gemma":[0.0001508365,0.001984771,0.943015,0.00002759225,0.0002719821,0.04824764,0.0003091737,0.0007499175,0.004152385,0.0004123011,0.0006439097,0.00003449278],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992925,0.0002365806,0.0001022311,0.0000360801,0.000008567553,0.000003396853,0.0000295863,0.000006385046,0.000284591],"genre_scores_gemma":[0.9994335,0.0001063028,0.000122631,0.00002991162,0.00001595996,0.000003399831,0.00004368916,0.000004495068,0.0002400723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002320232,"threshold_uncertainty_score":0.007761955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07301918080886562,"score_gpt":0.3619216805767536,"score_spread":0.288902499767888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}