{"id":"W2052117565","doi":"10.1172/jci10727","title":"Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes","year":2000,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":318,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Royal Victoria Hospital; Xenon Pharmaceuticals (Canada); McGill University Health Centre; Royal Victoria Regional Health Centre; University of British Columbia","funders":"Medical Research Council; Promotion and Mutual Aid Corporation for Private Schools of Japan; BC Children's Hospital; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Tangier disease; ABCA1; Cholesterol; Heterozygote advantage; Internal medicine; Endocrinology; Efflux; Compound heterozygosity; Familial hypercholesterolemia; Biology; ATP Binding Cassette Transporter 1; Coronary artery disease; Residual risk; Medicine; Genetics; Mutation; Genotype; Gene; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001662071,0.0002358992,0.0008296287,0.0001968669,0.00005205419,0.000083051,0.0000961872,0.0002032792,0.00004531337],"category_scores_gemma":[0.0007477847,0.0001865578,0.000151339,0.0001296259,0.000445172,0.000544618,0.00003663256,0.0007995331,0.00001286271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002336376,"about_ca_system_score_gemma":0.0001336466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001160068,"about_ca_topic_score_gemma":0.00002035037,"domain_scores_codex":[0.9969901,0.0004528873,0.001569572,0.0003236025,0.0004203204,0.0002434728],"domain_scores_gemma":[0.9978601,0.0005201016,0.0004397243,0.0002395441,0.00008233226,0.0008582351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008618942,0.0002455628,0.9251511,0.0001416923,0.00006945309,0.0003130148,0.0004371602,0.00002555798,0.001636351,0.000008940053,0.0002993997,0.07080984],"study_design_scores_gemma":[0.00724719,0.000752821,0.9879886,0.000846951,0.000215393,0.000459752,0.00002171879,0.0001930081,0.0001622852,0.0007058733,0.001252282,0.0001541192],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950117,0.0005068887,0.00001021424,0.00377015,0.0003027232,0.0003208288,0.00000954705,0.00001685622,0.00005111164],"genre_scores_gemma":[0.9932704,0.0004958967,0.0004510399,0.004115601,0.001320491,0.000005241262,0.00001220987,0.00002657697,0.0003025749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07065572,"threshold_uncertainty_score":0.7607606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07301918080886562,"score_gpt":0.3619216805767536,"score_spread":0.288902499767888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}