{"id":"W2052130438","doi":"10.1371/journal.ppat.1004347","title":"Transgenic Analysis of the Leishmania MAP Kinase MPK10 Reveals an Auto-inhibitory Mechanism Crucial for Stage-Regulated Activity and Parasite Viability","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; European Commission; Agence Nationale de la Recherche; University of Victoria","keywords":"Biology; Amastigote; Cell biology; Kinase; Phosphorylation; Protein kinase A; Transgene; Leishmania; Signal transduction; Biochemistry; Parasite hosting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007197507,0.0003795126,0.0001313356,0.0001653637,0.00008515456,0.0002139481,0.0002929067,0.0002663473,0.0009648118],"category_scores_gemma":[0.00008690651,0.0001749267,0.0002572842,0.0001052899,0.0002945387,0.0001498328,0.0002045017,0.0006222771,0.0005032914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00036878,"about_ca_system_score_gemma":0.0002043444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008946864,"about_ca_topic_score_gemma":0.001177718,"domain_scores_codex":[0.9999065,0.00000954408,0.000009443257,0.00002447853,0.00002559122,0.00002436667],"domain_scores_gemma":[0.9998761,0.00002041051,0.00004878786,0.00001286241,0.000008654149,0.00003313272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002761229,0.000009219149,0.00004132517,0.00001036782,0.000001322216,0.00002786043,0.000003834839,0.000023691,0.9996025,0.00004565871,0.000007793212,0.0001988314],"study_design_scores_gemma":[0.00001012184,0.0000900641,0.002516845,0.000004032095,0.00001138907,0.0002862449,0.00001750303,0.001329895,0.9942736,0.00004964618,0.001405543,0.000005152605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920529,0.000374804,0.005626945,0.0001038833,0.00001963722,0.0000273532,0.0006972478,0.0001666543,0.0009305685],"genre_scores_gemma":[0.9921079,0.00038816,0.003390864,0.00005494407,0.000006674249,0.00002833921,0.0008922905,0.00007986983,0.003050862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009648118,"threshold_uncertainty_score":0.003227651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03246295257288993,"score_gpt":0.3002488536422213,"score_spread":0.2677859010693313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}