{"id":"W2052174532","doi":"10.1002/pro.135","title":"Rate and extent of protein localization is controlled by peptide‐binding domain association kinetics and morphology","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Kinetics; Biophysics; Fusion protein; Chromosomal translocation; Receptor–ligand kinetics; Cell biology; Transport protein; Protein domain; Cytoskeleton; Biology; Nuclear localization sequence; Calmodulin; Chemistry; Biochemistry; Cell; Recombinant DNA; Receptor; Gene; Nucleus; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006490826,0.0001052248,0.0001738511,0.00006005045,0.0000910091,0.00003934572,0.0001359551,0.0001791228,0.00000458274],"category_scores_gemma":[0.0002307746,0.00009272772,0.00002029237,0.0001665018,0.0002830383,0.000006483778,0.0000890802,0.00005509773,6.59528e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001976082,"about_ca_system_score_gemma":0.00003788005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006595379,"about_ca_topic_score_gemma":0.000002405626,"domain_scores_codex":[0.9990205,0.00005409477,0.0002205202,0.0003480371,0.0001347657,0.0002221349],"domain_scores_gemma":[0.9994423,0.000005076186,0.0002137605,0.0001565385,0.0001281394,0.00005419684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009154299,0.00003277556,0.000264613,0.000006151315,0.000005593587,3.251482e-7,0.00002400216,0.000001240471,0.9972288,0.0001990936,0.00004679465,0.002099041],"study_design_scores_gemma":[0.001128292,0.0008953944,0.000925254,0.00001455024,0.000006842444,0.00000372988,0.00001912062,0.0001446258,0.9944541,0.0008199117,0.00147791,0.0001102394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953001,0.0004575959,0.002367577,0.001103628,0.00002840051,0.0006482387,0.00001223857,0.000006732799,0.00007552474],"genre_scores_gemma":[0.9972938,0.0001203334,0.002088857,0.0001686246,0.00002365488,0.00002380762,0.000008256493,0.000004800003,0.0002679168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002774697,"threshold_uncertainty_score":0.3781327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004773661641930233,"score_gpt":0.2245322269509815,"score_spread":0.2197585653090512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}