{"id":"W2052202737","doi":"10.1371/journal.pgen.1002611","title":"Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma","year":2012,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Public Health Ontario; Hospital for Sick Children","funders":"National Eye Institute; National Health and Medical Research Council; National Institutes of Health; Centre for Medical Systems Biology; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Moorfields Eye Hospital NHS Foundation Trust; Landelijke Stichting voor Blinden en Slechtzienden; Heidelberg Engineering; Hersenstichting; Medical Research Council; Oogfonds; Erasmus Medisch Centrum; ZonMw; Stichting Wetenschappelijk Onderzoek Oogziekenhuis; Wellcome Trust; Ophthalmic Research Institute of Australia; American Health Assistance Foundation; Erasmus Universiteit Rotterdam; Pfizer Australia; National Institute for Health and Care Research; Stichting Nederlands Oogheelkundig Onderzoek; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; King's College London; European Commission; Pfizer","keywords":"Glaucoma; Trabecular meshwork; Open angle glaucoma; Intraocular pressure; Ophthalmology; Genome-wide association study; Biology; Population; Myocilin; Ciliary body; Optic nerve; Genetic association; Genetics; Medicine; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001238778,0.0004673379,0.002383702,0.000130368,0.00006035083,0.00002925963,0.0004639954,0.0004636322,0.00006449543],"category_scores_gemma":[0.0000231279,0.0003593935,0.0002475282,0.0001698128,0.0001987752,0.0000312477,0.0005489365,0.0003516198,0.0000237413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002204274,"about_ca_system_score_gemma":0.0002051074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001663348,"about_ca_topic_score_gemma":0.00001768824,"domain_scores_codex":[0.997918,0.0001666928,0.0007787112,0.0003952614,0.0003433332,0.0003980808],"domain_scores_gemma":[0.998394,0.00007873752,0.0004250511,0.0007592567,0.00008133696,0.0002616745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002753607,0.0005471404,0.03812261,0.08211148,0.0005852601,0.00006522657,0.00007965501,1.808821e-8,0.0000509712,0.000004740225,0.0001795476,0.8782258],"study_design_scores_gemma":[0.0006360244,0.0005168366,0.01329058,0.01118883,0.01633289,0.0004580127,0.00001142429,0.00004363052,0.00021576,0.00002858959,0.9568186,0.0004588475],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.026113,0.9708054,0.000001905044,0.000009022702,0.0001161969,0.002045965,0.00005799951,0.00001853968,0.0008319699],"genre_scores_gemma":[0.001214897,0.9966198,0.001341682,0.00005873763,0.0001370188,0.0000722339,0.00008832839,0.0001132992,0.0003540054],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9566391,"threshold_uncertainty_score":0.9998858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04593602734839175,"score_gpt":0.3166220468040339,"score_spread":0.2706860194556421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}