{"id":"W2052202737","doi":"10.1371/journal.pgen.1002611","title":"Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma","year":2012,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Public Health Ontario; Hospital for Sick Children","funders":"National Eye Institute; National Health and Medical Research Council; National Institutes of Health; Centre for Medical Systems Biology; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Moorfields Eye Hospital NHS Foundation Trust; Landelijke Stichting voor Blinden en Slechtzienden; Heidelberg Engineering; Hersenstichting; Medical Research Council; Oogfonds; Erasmus Medisch Centrum; ZonMw; Stichting Wetenschappelijk Onderzoek Oogziekenhuis; Wellcome Trust; Ophthalmic Research Institute of Australia; American Health Assistance Foundation; Erasmus Universiteit Rotterdam; Pfizer Australia; National Institute for Health and Care Research; Stichting Nederlands Oogheelkundig Onderzoek; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; King's College London; European Commission; Pfizer","keywords":"Glaucoma; Trabecular meshwork; Open angle glaucoma; Intraocular pressure; Ophthalmology; Genome-wide association study; Biology; Population; Myocilin; Ciliary body; Optic nerve; Genetic association; Genetics; Medicine; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007213153,0.0009162356,0.0007731712,0.001289517,0.0005201074,0.0008947026,0.0007120398,0.001359126,0.003149253],"category_scores_gemma":[0.00355093,0.0004058942,0.0014905,0.002335597,0.0009070184,0.0004047013,0.0009044795,0.0006871671,0.000239894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004574129,"about_ca_system_score_gemma":0.0005518287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009507377,"about_ca_topic_score_gemma":0.009649953,"domain_scores_codex":[0.9984208,0.0003425454,0.0001717427,0.0006991347,0.0002199178,0.0001457905],"domain_scores_gemma":[0.9977488,0.0006715047,0.00105225,0.0001793329,0.00009360358,0.000254454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001341752,0.00006871767,0.9724408,0.0003016533,0.004216615,0.002770593,0.000220154,0.000377559,0.007888045,0.0007973758,0.0008264185,0.00875041],"study_design_scores_gemma":[0.00009965395,0.0001273136,0.993541,0.0000672897,0.001675483,0.002000903,0.00009532672,0.0005894585,0.0004232971,0.0008336136,0.0005303952,0.0000161975],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9846549,0.01042673,0.001167717,0.000540034,0.0001145877,0.00002578012,0.001537807,0.00004163187,0.001490826],"genre_scores_gemma":[0.9975042,0.001057324,0.0005612033,0.00006721046,0.00006060342,0.00001432886,0.0004488901,0.00001008975,0.0002762193],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.009507377,"threshold_uncertainty_score":0.01890409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04593602734839175,"score_gpt":0.3166220468040339,"score_spread":0.2706860194556421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}