{"id":"W2052211754","doi":"10.1128/aac.00602-11","title":"Identification of Hopanoid Biosynthesis Genes Involved in Polymyxin Resistance in Burkholderia multivorans","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Polymyxin; Biology; Microbiology; Polymyxin B; Burkholderia cepacia complex; Mutant; Lipid A; Bacterial outer membrane; Transposable element; Burkholderia; Genetics; Gene; Bacteria; Antibiotics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395408,0.0003095522,0.0002281936,0.00043775,0.000115938,0.0002475636,0.0001852277,0.0002246709,0.0004117884],"category_scores_gemma":[0.0001792903,0.0001497,0.0002915029,0.0003399469,0.0001304864,0.0001054587,0.000277725,0.0002930209,0.0002606475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474968,"about_ca_system_score_gemma":0.0001955097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391944,"about_ca_topic_score_gemma":0.0009824113,"domain_scores_codex":[0.9998739,0.00001715236,0.00001985075,0.00002901684,0.00002869274,0.00003129544],"domain_scores_gemma":[0.9998179,0.00002986702,0.0000682286,0.00001642607,0.00002250353,0.00004516617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007348813,0.00002529737,0.001171036,0.0000143876,0.000002692227,0.00005759453,0.00001560285,0.0000418668,0.9978501,0.00001539599,0.000006449879,0.0007260457],"study_design_scores_gemma":[0.00003968291,0.0005945103,0.1205998,0.00002620445,0.00005804365,0.001482602,0.0003749298,0.002599435,0.8722523,0.0001333096,0.001817039,0.00002222403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978023,0.0002015535,0.001161084,0.00003571262,0.000005286665,0.00002528427,0.0005552464,0.00002380485,0.0001898225],"genre_scores_gemma":[0.9935322,0.0002086249,0.0031667,0.00004072201,0.000005515767,0.00003147665,0.002073786,0.00001771171,0.0009230673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391944,"threshold_uncertainty_score":0.002767682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485320769865623,"score_gpt":0.2362774306337568,"score_spread":0.2214242229351005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}