{"id":"W2052272381","doi":"10.1074/jbc.m112.415497","title":"A Limited 4 Å Radial Displacement of the S4-S5 Linker Is Sufficient for Internal Gate Closing in Kv Channels","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; National Supercomputing Center, Korea Institute of Science and Technology Information; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Ion channel; Voltage-gated ion channel; Ion; Chemical physics; Coupling (piping); Chemistry; Biophysics; Materials science; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004007872,0.0001015539,0.0001568896,0.00002023996,0.00003314458,0.000008572455,0.0001463437,0.0001924322,0.00005091698],"category_scores_gemma":[0.0001899729,0.00006067095,0.0002120253,0.00006947691,0.00006932292,0.00000568494,0.00006460931,0.0001332059,4.76167e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003359078,"about_ca_system_score_gemma":0.00002946847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.996825e-7,"about_ca_topic_score_gemma":1.600142e-7,"domain_scores_codex":[0.9991596,0.00003649693,0.0003913496,0.0001061515,0.0001176542,0.0001887936],"domain_scores_gemma":[0.9993641,0.00002439243,0.0003224312,0.0001012961,0.0001155934,0.00007216919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006874613,0.0002523212,0.01086672,0.0000292008,0.00004003993,4.552023e-7,0.000130015,0.0003581663,0.9861475,0.0000113067,0.00100262,0.0004742393],"study_design_scores_gemma":[0.00106152,0.0002637423,0.005584483,0.00006108399,0.00001509679,0.00004448714,0.0001575401,0.0006147905,0.978231,0.00003415369,0.01383006,0.0001020044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962135,0.0003981287,0.002102621,0.0003734995,0.0006842266,0.00009581094,0.0000117205,0.00000146649,0.0001190446],"genre_scores_gemma":[0.998171,0.00006515592,0.0001171897,0.0002039322,0.001183395,0.000004413916,0.00001465108,0.000005725937,0.0002345648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01282744,"threshold_uncertainty_score":0.247409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0309662386448077,"score_gpt":0.2756753433751887,"score_spread":0.244709104730381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}