{"id":"W2052300490","doi":"10.1097/fpc.0b013e3283498147","title":"Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants","year":2011,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"UGT2B7; Exon; Alternative splicing; Biology; Glucuronidation; RNA splicing; Gene isoform; Exon skipping; Messenger RNA; Locus (genetics); Genetics; Gene; Molecular biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000806178,0.000660494,0.0005208369,0.0001515125,0.001687601,0.00004916417,0.0008469403,0.0003264415,0.001945209],"category_scores_gemma":[0.00002691698,0.000593217,0.0002267246,0.0002836577,0.0003445185,0.0001153997,0.001210377,0.0007679727,0.0001969888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399327,"about_ca_system_score_gemma":0.00008560771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003197599,"about_ca_topic_score_gemma":0.00005484193,"domain_scores_codex":[0.9965968,0.0004008522,0.0005711225,0.0009718475,0.0004260076,0.001033383],"domain_scores_gemma":[0.9977568,0.0002636676,0.0002883984,0.0004240863,0.0002667282,0.00100036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001646724,0.0004351925,0.005742841,0.00004066234,0.0008208257,0.00005634669,0.01797288,0.000717008,0.9445902,0.0001527913,0.01381797,0.01400655],"study_design_scores_gemma":[0.004878482,0.0001688414,0.008590653,0.00001176201,0.001422935,0.00008102992,0.0004888162,0.01237993,0.7809516,0.001504426,0.1885359,0.0009856166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790829,0.009683521,0.003166561,0.0009660607,0.00190877,0.001453954,0.002631976,0.0000788354,0.001027351],"genre_scores_gemma":[0.9705315,0.01335726,0.001136126,0.01321508,0.0002712223,0.00008346725,0.00006665042,0.00009301228,0.001245741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1747179,"threshold_uncertainty_score":0.9996519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.109045257930295,"score_gpt":0.3443647544987822,"score_spread":0.2353194965684872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}