{"id":"W2052337414","doi":"10.1038/nmeth.1669","title":"TopFIND, a knowledgebase linking protein termini with function","year":2011,"lang":"en","type":"letter","venue":"Nature Methods","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Computational biology; Protein function; Function (biology); Chemistry; Cell biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0007695197,0.0004750165,0.000809219,0.0005795839,0.0001028656,0.00004064474,0.0001434768,0.002933861,0.001180545],"category_scores_gemma":[0.0002453128,0.0003306751,0.0003954155,0.0005429154,0.00009572179,0.00007026674,0.00004846794,0.007663991,0.0001063962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001100033,"about_ca_system_score_gemma":0.0002457043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001224621,"about_ca_topic_score_gemma":0.00001055193,"domain_scores_codex":[0.9975318,0.0005472177,0.0003668811,0.0006963363,0.0004605622,0.0003971614],"domain_scores_gemma":[0.9984053,0.0001115547,0.0002448301,0.000745692,0.0003656431,0.0001269949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006501763,0.0002112011,0.00009703432,0.001994832,0.0009689161,0.003019357,0.0002350185,1.51477e-7,0.01050107,0.0001241449,0.8662724,0.1159257],"study_design_scores_gemma":[0.001018711,0.0004191463,0.00009460176,0.003605565,0.00100973,0.0002086512,0.00001452828,0.00003023086,0.0122739,0.0004004078,0.9804876,0.0004369334],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003512673,0.00441533,0.2051894,0.6224163,0.001398046,0.004021795,0.0001133325,0.001305235,0.1576279],"genre_scores_gemma":[0.0009659654,0.000005854693,0.3107944,0.6167406,0.009063206,0.0001976799,0.0009422125,0.0001462967,0.0611437],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1154888,"threshold_uncertainty_score":0.9999145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02702505720151386,"score_gpt":0.3510230566869473,"score_spread":0.3239979994854334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}