{"id":"W2052337414","doi":"10.1038/nmeth.1669","title":"TopFIND, a knowledgebase linking protein termini with function","year":2011,"lang":"en","type":"letter","venue":"Nature Methods","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Computational biology; Protein function; Function (biology); Chemistry; Cell biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004031913,0.0006961206,0.001463286,0.001414848,0.00100549,0.002607568,0.001899516,0.01214093,0.006180676],"category_scores_gemma":[0.01924677,0.0007007084,0.0008432218,0.0008096783,0.001320183,0.003214389,0.001397127,0.0171457,0.006870259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001570287,"about_ca_system_score_gemma":0.001477997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009335437,"about_ca_topic_score_gemma":0.002421166,"domain_scores_codex":[0.998611,0.0003519075,0.0002291035,0.0001469679,0.0005526575,0.0001083633],"domain_scores_gemma":[0.9881281,0.008652445,0.0004886972,0.0007856956,0.001233216,0.0007118023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004243754,0.00008799624,0.00067304,0.0004920634,0.00007971936,0.001961939,0.00006495339,0.0003072123,0.003693736,0.005202581,0.9092508,0.07776159],"study_design_scores_gemma":[0.0004696285,0.0001449107,0.0009719725,0.0004130781,0.0002123371,0.005221651,0.00007930795,0.00438918,0.00524871,0.03994181,0.9428372,0.00007025639],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.00321896,0.01773617,0.0210131,0.9087765,0.03692392,0.0001125035,0.00405355,0.001410005,0.006755275],"genre_scores_gemma":[0.02971177,0.045677,0.07150516,0.7334573,0.07939514,0.0006139211,0.008409521,0.0007188055,0.03051141],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.01214093,"threshold_uncertainty_score":0.02132303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02702505720151386,"score_gpt":0.3510230566869473,"score_spread":0.3239979994854334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}