{"id":"W2052341771","doi":"10.1002/eji.200636620","title":"Pathologic expression of MHC class II is driven by mitogen‐activated protein kinases","year":2007,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Institut National de la Santé et de la Recherche Médicale; Canadian Institutes of Health Research; Cancer Research Society; Association pour la Recherche sur le Cancer","keywords":"CIITA; MAPK/ERK pathway; Biology; Enhancer; Kinase; Transcription factor; Cancer research; Microphthalmia-associated transcription factor; Cell biology; Protein kinase A; MHC class I; MHC class II; Transactivation; Mitogen-activated protein kinase; Molecular biology; Major histocompatibility complex; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112356,0.000397297,0.0001282283,0.000171922,0.0001193973,0.0002080042,0.0001340213,0.0001232101,0.001393401],"category_scores_gemma":[0.00008662586,0.0001085718,0.0001644272,0.00007779006,0.0001650613,0.0001106323,0.0001788676,0.0004724917,0.0006256638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002818201,"about_ca_system_score_gemma":0.0001505678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002347158,"about_ca_topic_score_gemma":0.0002539505,"domain_scores_codex":[0.9998701,0.00001968697,0.000007255546,0.00002584541,0.00004108916,0.00003600403],"domain_scores_gemma":[0.9999185,0.00001266988,0.0000257619,0.00001023741,0.0000121336,0.00002066169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001475109,0.000004758625,0.00005849551,0.00000932578,5.119196e-7,0.00001645601,0.000002409806,0.000007988311,0.9995772,0.00005520109,0.00001151632,0.0002413537],"study_design_scores_gemma":[0.000009455573,0.0001106565,0.003686468,0.0000065004,0.00000463277,0.0003306984,0.00001992141,0.0005716655,0.9927552,0.00007602401,0.002426626,0.000002118649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870417,0.001691358,0.007264037,0.0001129018,0.00006465476,0.00004052912,0.0003158972,0.000119702,0.003349257],"genre_scores_gemma":[0.992377,0.0009507122,0.002820773,0.00003386305,0.00001574706,0.00003249071,0.0005297577,0.00001871091,0.003221025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001393401,"threshold_uncertainty_score":0.004661441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009438724971073143,"score_gpt":0.2166225842017941,"score_spread":0.2071838592307209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}