{"id":"W2052341771","doi":"10.1002/eji.200636620","title":"Pathologic expression of MHC class II is driven by mitogen‐activated protein kinases","year":2007,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Institut National de la Santé et de la Recherche Médicale; Canadian Institutes of Health Research; Cancer Research Society; Association pour la Recherche sur le Cancer","keywords":"CIITA; MAPK/ERK pathway; Biology; Enhancer; Kinase; Transcription factor; Cancer research; Microphthalmia-associated transcription factor; Cell biology; Protein kinase A; MHC class I; MHC class II; Transactivation; Mitogen-activated protein kinase; Molecular biology; Major histocompatibility complex; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005760742,0.0001566143,0.0002454916,0.00009055645,0.0000764658,0.000005568344,0.0003628806,0.0001090579,0.00003826855],"category_scores_gemma":[0.0001534459,0.0001245832,0.0001422395,0.00007144694,0.0001446488,0.000006719099,0.0001959253,0.0002216475,0.000009949175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001078615,"about_ca_system_score_gemma":0.0000426751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001505764,"about_ca_topic_score_gemma":3.870492e-7,"domain_scores_codex":[0.9985284,0.0003701029,0.000553144,0.0001825475,0.0001159703,0.0002498806],"domain_scores_gemma":[0.9988199,0.00001468788,0.0006270733,0.000275328,0.0001965741,0.00006642572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005253416,0.0001263117,0.0002968746,0.000007850523,0.00005975508,0.0001780815,0.0001988239,0.000001416647,0.989034,0.00000899481,0.005281387,0.004281139],"study_design_scores_gemma":[0.0009981162,0.002880508,0.002066625,0.0000544179,0.00001320686,0.0002808791,0.0001430114,2.53689e-7,0.9446854,0.00001280483,0.04874501,0.0001197559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935858,0.002830919,0.001379109,0.0000850451,0.0003133534,0.00009710906,0.00001805238,0.000008619997,0.001681949],"genre_scores_gemma":[0.9981596,0.0001678705,0.0007355188,0.000118975,0.0001558787,7.042743e-7,0.00002081559,0.00003213599,0.0006085396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04434861,"threshold_uncertainty_score":0.5080353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009438724971073143,"score_gpt":0.2166225842017941,"score_spread":0.2071838592307209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}