{"id":"W2052343768","doi":"10.1021/es0000605","title":"A Novel in Vivo Bioassay for (Xeno-)estrogens Using Transgenic Zebrafish","year":2000,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Zebrafish; Biology; Transgene; Luciferase; Estrogen receptor; Transactivation; In vivo; Reporter gene; Vitellogenin; Cell biology; Gene; Gene expression; Genetics; Transfection","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000178002,0.0001190456,0.00009757186,0.000147313,0.0001597296,0.00001112964,0.0002838185,0.0001628639,0.0000951722],"category_scores_gemma":[0.00001012276,0.0001177699,0.00005149549,0.000328088,0.000908556,0.000006810751,0.00006547084,0.00006829508,0.000006691663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006281712,"about_ca_system_score_gemma":0.00003970237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001175626,"about_ca_topic_score_gemma":0.00001577009,"domain_scores_codex":[0.9987717,0.000005546393,0.000156415,0.0005851595,0.0001111196,0.0003700047],"domain_scores_gemma":[0.9996295,0.000001544731,0.00003442664,0.0002823681,0.000004691011,0.00004744477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002280102,0.0001024802,0.00198868,0.00000135897,0.000004198384,4.423512e-7,0.00001616794,0.0004800805,0.9921924,0.00003540785,0.000009288883,0.005146652],"study_design_scores_gemma":[0.0003915238,0.000334211,0.001898666,0.000003339107,0.000007817551,0.00005283755,0.0001155616,0.000456836,0.9717208,0.00009140409,0.0247617,0.0001653745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996742,0.0002421828,0.002264783,0.000219408,0.0000631755,0.0002642028,0.00002557386,0.00001425577,0.0001644305],"genre_scores_gemma":[0.9948813,0.0001341559,0.004442824,0.00005728133,0.00005913845,0.00002510009,0.000005950554,0.00001385041,0.0003804554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02475241,"threshold_uncertainty_score":0.4802519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008593000572000901,"score_gpt":0.2293174910434337,"score_spread":0.2207244904714328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}