{"id":"W2052343768","doi":"10.1021/es0000605","title":"A Novel in Vivo Bioassay for (Xeno-)estrogens Using Transgenic Zebrafish","year":2000,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Zebrafish; Biology; Transgene; Luciferase; Estrogen receptor; Transactivation; In vivo; Reporter gene; Vitellogenin; Cell biology; Gene; Gene expression; Genetics; Transfection","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003608744,0.001146711,0.0004933771,0.0006013743,0.0003624325,0.0002626865,0.0006166973,0.0005874862,0.00119971],"category_scores_gemma":[0.0001828081,0.0004489216,0.0004640509,0.0002770979,0.0004564262,0.0003053448,0.000341207,0.0008478613,0.000384123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006336141,"about_ca_system_score_gemma":0.0006637713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003943417,"about_ca_topic_score_gemma":0.0073488,"domain_scores_codex":[0.9996921,0.00003477453,0.00003152006,0.0001005792,0.0001038439,0.00003737781],"domain_scores_gemma":[0.9998327,0.00002426081,0.00005370492,0.00002242301,0.00003153448,0.00003523412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001316712,0.000009513543,0.0000591535,0.0000144716,0.000001894064,0.00001429395,0.000004757449,0.00002104551,0.9995896,0.00002589889,0.00001363732,0.0002326344],"study_design_scores_gemma":[0.00002321654,0.0005554752,0.001714298,0.000005566604,0.00003243328,0.0001882994,0.00001069632,0.0004451157,0.9954035,0.00004353151,0.001565877,0.00001194048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8792909,0.001616926,0.1088474,0.0003727455,0.0001618675,0.001075796,0.0028961,0.001245502,0.004492745],"genre_scores_gemma":[0.866662,0.004312192,0.1068367,0.0003165479,0.0000410924,0.001658218,0.003711223,0.0002349067,0.01622704],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.003943417,"threshold_uncertainty_score":0.007840931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008593000572000901,"score_gpt":0.2293174910434337,"score_spread":0.2207244904714328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}