{"id":"W2052348628","doi":"10.1039/c1em10511f","title":"A tool for rapid screening of direct DNA agents using reaction rates and relative interaction potency: towards screening environmental contaminants for hazard","year":2011,"lang":"en","type":"article","venue":"Journal of Environmental Monitoring","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Health Canada","keywords":"Chemistry; Potency; Pyrene; Metabolite; Carcinogen; DNA; Epoxide; Kinetics; In vitro; Toxicology; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003623346,0.002435931,0.001606051,0.002028321,0.0003795096,0.001150524,0.001546043,0.003028985,0.002262085],"category_scores_gemma":[0.006104333,0.001271043,0.0009375999,0.001073232,0.0009263169,0.001496854,0.001224878,0.00289502,0.003419379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005359179,"about_ca_system_score_gemma":0.0008253696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004814193,"about_ca_topic_score_gemma":0.0009260795,"domain_scores_codex":[0.9959078,0.0009194926,0.0002435769,0.0007996536,0.001966756,0.0001627469],"domain_scores_gemma":[0.9945757,0.003007083,0.0007454382,0.000456002,0.0009808434,0.0002349254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004423492,0.0000583341,0.0003625235,0.0001996721,0.00002867043,0.00002293578,0.00001929059,0.0001210754,0.9898092,0.0001124071,0.0001585348,0.009063205],"study_design_scores_gemma":[0.000009681354,0.0002874569,0.00103468,0.00002137772,0.00005302787,0.0003576043,0.0000213199,0.00307261,0.9911373,0.00009534527,0.003877654,0.00003186323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.05218424,0.006021941,0.9334757,0.000344824,0.000252547,0.0008443658,0.001155669,0.004089926,0.00163082],"genre_scores_gemma":[0.1726425,0.007701414,0.8082552,0.0007620096,0.0001278078,0.001943944,0.001785475,0.0003827204,0.006399012],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003623346,"threshold_uncertainty_score":0.01916236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0466934443646762,"score_gpt":0.2939597193026489,"score_spread":0.2472662749379727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}