{"id":"W2052348628","doi":"10.1039/c1em10511f","title":"A tool for rapid screening of direct DNA agents using reaction rates and relative interaction potency: towards screening environmental contaminants for hazard","year":2011,"lang":"en","type":"article","venue":"Journal of Environmental Monitoring","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Health Canada","keywords":"Chemistry; Potency; Pyrene; Metabolite; Carcinogen; DNA; Epoxide; Kinetics; In vitro; Toxicology; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002977549,0.0001537713,0.0002273835,0.00006968635,0.0001199996,0.00001202593,0.00006888783,0.00009363526,0.00000701644],"category_scores_gemma":[0.00002677365,0.0001515886,0.0001829447,0.00001776508,0.0000557183,0.00004279107,0.00006827431,0.00008800323,9.49781e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008492437,"about_ca_system_score_gemma":0.00001249848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001569245,"about_ca_topic_score_gemma":8.423725e-7,"domain_scores_codex":[0.9990485,0.00003977115,0.0003973634,0.0001920036,0.0001529584,0.0001693929],"domain_scores_gemma":[0.9993074,0.00002625794,0.0004963996,0.00009422683,0.00001434708,0.00006138906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006997405,0.0001048543,0.04541301,0.00001804005,0.0002066282,0.000002543032,0.0002599276,0.00004499166,0.9189721,4.541309e-7,0.0000027522,0.03427495],"study_design_scores_gemma":[0.001062774,0.00107013,0.2728832,0.00009859965,0.0001335734,0.00005297979,0.001277242,0.0002830607,0.7226718,0.000008296451,0.0003230442,0.0001352813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831161,0.0006415621,0.01556182,0.000005306723,0.0002897971,0.0002964102,0.0000661853,0.000001518535,0.00002122826],"genre_scores_gemma":[0.9763133,0.0003783703,0.02296099,0.000006440191,0.000257539,0.00001042497,0.00001303899,0.00002395636,0.00003595209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2274702,"threshold_uncertainty_score":0.6181602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0466934443646762,"score_gpt":0.2939597193026489,"score_spread":0.2472662749379727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}