{"id":"W2052365021","doi":"10.1074/jbc.m110.115022","title":"TRIF Modulates TLR5-dependent Responses by Inducing Proteolytic Degradation of TLR5","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; McGill University; Flight Attendant Medical Research Institute","keywords":"TRIF; TLR5; Signal transducing adaptor protein; Cell biology; TLR3; TLR2; HEK 293 cells; Chemistry; Protein degradation; Toll-like receptor; Signal transduction; Biology; Receptor; Biochemistry; TLR4; Innate immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000247025,0.000358751,0.0001950455,0.0002217001,0.0001486814,0.0002463209,0.000153542,0.0002832432,0.001155418],"category_scores_gemma":[0.0001449621,0.0001054713,0.0003683313,0.00009659192,0.0001575531,0.0002320346,0.0002103316,0.0004849986,0.0004421011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002529185,"about_ca_system_score_gemma":0.0001602989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000276837,"about_ca_topic_score_gemma":0.0003515311,"domain_scores_codex":[0.9996713,0.00009202694,0.00003512296,0.00003715307,0.00005921692,0.0001051277],"domain_scores_gemma":[0.9998715,0.00001324894,0.00004930702,0.00001124403,0.00002033564,0.00003426732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001638477,0.00002297252,0.0002359456,0.00007377592,0.000006079842,0.00004647241,0.000008707277,0.00003893655,0.998434,0.00006535773,0.00004697172,0.0008568647],"study_design_scores_gemma":[0.00002176162,0.0002849773,0.006540486,0.00001555128,0.00002212119,0.0004508487,0.00003751239,0.001088395,0.9889082,0.0000347242,0.002589602,0.000005626817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898919,0.004030893,0.003160639,0.0001561715,0.00004268114,0.00004074151,0.0004361212,0.00006597282,0.002174826],"genre_scores_gemma":[0.9940316,0.001534379,0.002135735,0.0001203503,0.00001520656,0.00003228917,0.0008005092,0.00001163735,0.00131831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155418,"threshold_uncertainty_score":0.003865242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584067184242298,"score_gpt":0.2444313459899906,"score_spread":0.2285906741475676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}