{"id":"W2052373965","doi":"10.1038/ni.2241","title":"A new path to IL-1β production controlled by caspase-8","year":2012,"lang":"en","type":"letter","venue":"Nature Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Inflammasome; Proinflammatory cytokine; Caspase 1; Cytokine; Biology; Stimulation; Immunology; Cell biology; Microbiology; Inflammation; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0001778966,0.0005299841,0.0006552824,0.0001558034,0.0001083439,0.00002944449,0.0005132103,0.004643816,0.0001462056],"category_scores_gemma":[0.00034079,0.0004814553,0.0003032204,0.0001432947,0.00007386052,0.00000653945,0.0001871416,0.002701984,0.0002388639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004808502,"about_ca_system_score_gemma":0.0002206516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005733506,"about_ca_topic_score_gemma":0.00001369723,"domain_scores_codex":[0.9976715,0.0001926667,0.0003976049,0.0007474595,0.0001915727,0.0007992028],"domain_scores_gemma":[0.9985396,0.00001905683,0.0002427467,0.0009500207,0.0001859883,0.00006260316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004487891,0.00002160916,0.000009124957,0.00001725669,0.0003836022,0.000009846601,0.00003361965,3.761741e-7,0.3237281,0.000004880117,0.6730408,0.002302047],"study_design_scores_gemma":[0.001944765,0.0003691256,0.00004761787,0.00002186703,0.0001065445,0.00007284131,0.00001890959,1.222083e-7,0.07001986,0.00002333971,0.9268735,0.0005015124],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04209953,0.1525036,0.0003359044,0.783131,0.01426311,0.003104363,0.0002681638,0.000130873,0.004163435],"genre_scores_gemma":[0.0325699,0.002243033,0.0006508273,0.8089882,0.01801235,0.0004542458,0.01205505,0.0003132282,0.1247132],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2538327,"threshold_uncertainty_score":0.9997637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002651905791620384,"score_gpt":0.2135446426946936,"score_spread":0.2108927369030732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}