{"id":"W2052374211","doi":"10.1016/j.cellimm.2009.06.009","title":"In vitro activation and differentiation of naïve CD4+ and CD8+ T cells into HCV Core- and NS3-specific armed effector cells: A new role for CD4+ T cells","year":2009,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cytotoxic T cell; Effector; Interleukin 21; Priming (agriculture); CD40; Antigen-presenting cell; IL-2 receptor; CD8; Granzyme; T cell; Cell biology; Natural killer T cell; Antigen; Molecular biology; Perforin; Immunology; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002691415,0.0002361355,0.0005754965,0.0003897486,0.00007229775,0.0000283636,0.00009414243,0.0003045654,0.00004839358],"category_scores_gemma":[0.00008372144,0.0002299713,0.00005489793,0.0002053249,0.0002003446,0.0001396011,0.00007437831,0.0003089724,0.0000102762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001118927,"about_ca_system_score_gemma":0.00008064514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002724335,"about_ca_topic_score_gemma":0.00001842801,"domain_scores_codex":[0.9983925,0.000142674,0.0004226318,0.0004601968,0.0001860432,0.0003959235],"domain_scores_gemma":[0.9989752,0.0003383044,0.000157204,0.0003064868,0.00008721134,0.0001356325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001251814,0.0001554297,0.0005151088,0.0001651839,0.00005162747,0.00001036182,0.001170385,8.773769e-7,0.9481642,0.00008499718,0.0002299766,0.04820006],"study_design_scores_gemma":[0.004487071,0.001017522,0.008555464,0.00008365342,0.00004042376,0.000004204805,0.0001221215,0.0009278385,0.9789947,0.0008295559,0.004761886,0.0001755735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920214,0.003730692,0.002202953,0.0004361122,0.0001652272,0.001307571,0.00001569088,0.00002335217,0.00009698111],"genre_scores_gemma":[0.9962764,0.001730295,0.001334385,0.00009080319,0.00008777846,0.00003444354,0.00009363583,0.00003080053,0.0003214902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04802449,"threshold_uncertainty_score":0.9377955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725728645420859,"score_gpt":0.2711813873513637,"score_spread":0.2539241008971551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}