{"id":"W2052457877","doi":"10.1007/bf03033790","title":"Excitotoxicity of quinolinic acid: Modulation by endogenous antagonists","year":2000,"lang":"en","type":"article","venue":"Neurotoxicity Research","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Quinolinic acid; Kynurenic acid; Excitotoxicity; NMDA receptor; Neuroprotection; Chemistry; Neurotoxicity; Kynurenine; Pharmacology; Picolinic acid; Glutamate receptor; Kynurenine pathway; Biochemistry; Receptor; Biology; Tryptophan","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005959752,0.0002016443,0.0002762208,0.0002281642,0.0003844961,0.00008061346,0.0007852407,0.0001501123,0.001929345],"category_scores_gemma":[0.0004977057,0.0002004712,0.0001213419,0.001088772,0.000667778,0.0002495406,0.0001248373,0.0006761063,0.0004113198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005284425,"about_ca_system_score_gemma":0.0001182281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001600762,"about_ca_topic_score_gemma":0.0000170091,"domain_scores_codex":[0.9957278,0.000965941,0.000423565,0.0007473002,0.001317699,0.0008177045],"domain_scores_gemma":[0.9985139,0.0004499738,0.00007701863,0.000655889,0.00009385945,0.00020941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001563581,0.0003914906,0.0003605724,0.00003388881,0.000002453515,0.00002252954,0.0001732347,0.00002116138,0.9723582,0.0001626199,0.001732932,0.02458454],"study_design_scores_gemma":[0.0006935442,0.0004067977,0.002492008,0.00001055648,9.128535e-7,0.00002892123,0.00002981381,0.0005483901,0.9900085,0.0007462947,0.004868739,0.0001655068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856806,0.00006097472,0.00001960796,0.0003183539,0.00006939076,0.001106569,0.00008380062,0.0001160454,0.01254466],"genre_scores_gemma":[0.9981968,0.0002899727,0.00002161466,0.0004397204,0.00007128486,0.00007776568,0.000006125326,0.00003787587,0.0008588022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02441903,"threshold_uncertainty_score":0.998983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1482111772986111,"score_gpt":0.3647515399555101,"score_spread":0.216540362656899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}