{"id":"W2052457877","doi":"10.1007/bf03033790","title":"Excitotoxicity of quinolinic acid: Modulation by endogenous antagonists","year":2000,"lang":"en","type":"article","venue":"Neurotoxicity Research","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Quinolinic acid; Kynurenic acid; Excitotoxicity; NMDA receptor; Neuroprotection; Chemistry; Neurotoxicity; Kynurenine; Pharmacology; Picolinic acid; Glutamate receptor; Kynurenine pathway; Biochemistry; Receptor; Biology; Tryptophan","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000264254,0.0003477898,0.0003669425,0.0002478557,0.0002372855,0.0003203132,0.000415554,0.0003544181,0.001648958],"category_scores_gemma":[0.0003969729,0.0001774361,0.0002136947,0.0001720183,0.0003544472,0.0004701082,0.0001648905,0.0003998087,0.0002203572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003171615,"about_ca_system_score_gemma":0.0002609464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001245066,"about_ca_topic_score_gemma":0.002673937,"domain_scores_codex":[0.9998671,0.00005127331,0.0000107929,0.00001130786,0.00001439369,0.00004504562],"domain_scores_gemma":[0.9997943,0.00006322362,0.00005210284,0.00002343935,0.00003396302,0.00003294557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007522104,0.0002093251,0.0003875972,0.0002114748,0.00004645304,0.0002978348,0.0001159029,0.0001959222,0.9824203,0.001037185,0.0002039736,0.007351892],"study_design_scores_gemma":[0.0005349488,0.006248932,0.00880187,0.00004458971,0.0001700587,0.0009026051,0.0002154225,0.002154773,0.9767177,0.0004740708,0.003705116,0.00003003374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860282,0.00955734,0.0014393,0.0001995543,0.0000473963,0.00003987878,0.0001037326,0.00004809808,0.002536641],"genre_scores_gemma":[0.9946391,0.003995121,0.0004526155,0.00003933286,0.00002588551,0.00001749973,0.00006808051,0.000007092542,0.0007553587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001648958,"threshold_uncertainty_score":0.00551635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1482111772986111,"score_gpt":0.3647515399555101,"score_spread":0.216540362656899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}