{"id":"W2052468011","doi":"10.1016/j.chom.2008.02.004","title":"Caspase-12 Modulates NOD Signaling and Regulates Antimicrobial Peptide Production and Mucosal Immunity","year":2008,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Inflammasome; NOD1; NOD2; Biology; Cell biology; Innate immune system; Nod; Antimicrobial peptides; Signal transduction; Caspase; Caspase 1; Signal transducing adaptor protein; Microbiology; Receptor; Inflammation; Immunology; Apoptosis; Antimicrobial; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003758736,0.0004986544,0.0005414679,0.0005223839,0.0002995929,0.0009767272,0.0004322246,0.0008115944,0.00294145],"category_scores_gemma":[0.0003981307,0.000378172,0.0003652383,0.000271964,0.0006089105,0.0009968907,0.0005463757,0.00142072,0.001003335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006342249,"about_ca_system_score_gemma":0.0002133364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001497638,"about_ca_topic_score_gemma":0.000238706,"domain_scores_codex":[0.9995978,0.00009001146,0.00003967791,0.00008467552,0.00006667461,0.0001211259],"domain_scores_gemma":[0.9996903,0.00003139221,0.00009827095,0.00003910074,0.00005504242,0.00008584368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002073867,0.00007583401,0.0007826438,0.0001045413,0.00001357602,0.0001963493,0.00002607058,0.0001022822,0.9916273,0.0005783106,0.0001765157,0.004242676],"study_design_scores_gemma":[0.0002752779,0.0006029147,0.01830247,0.00003168579,0.00004859208,0.001475287,0.0001719066,0.002094675,0.9705158,0.001475824,0.0049824,0.0000231049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738328,0.01297,0.006362274,0.001071539,0.0002491395,0.00006464619,0.0007023035,0.0002284979,0.004518779],"genre_scores_gemma":[0.9912418,0.00184633,0.002209728,0.0001014358,0.00003963108,0.00003440218,0.0003756125,0.00003276164,0.004118345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00294145,"threshold_uncertainty_score":0.00984019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006130587459720418,"score_gpt":0.1878261773127268,"score_spread":0.1816955898530064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}