{"id":"W2052468011","doi":"10.1016/j.chom.2008.02.004","title":"Caspase-12 Modulates NOD Signaling and Regulates Antimicrobial Peptide Production and Mucosal Immunity","year":2008,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Inflammasome; NOD1; NOD2; Biology; Cell biology; Innate immune system; Nod; Antimicrobial peptides; Signal transduction; Caspase; Caspase 1; Signal transducing adaptor protein; Microbiology; Receptor; Inflammation; Immunology; Apoptosis; Antimicrobial; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100188,0.000203138,0.0001613077,0.00004848662,0.0003287165,0.00002959336,0.0000928219,0.0001447844,0.00001061155],"category_scores_gemma":[0.00003176652,0.000209473,0.00005624156,0.00005402328,0.0002448021,0.00001362546,0.000149698,0.0001260174,0.000007039618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007890445,"about_ca_system_score_gemma":0.00003903407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001036907,"about_ca_topic_score_gemma":0.00002959141,"domain_scores_codex":[0.9990714,0.00004761666,0.0001932841,0.0003711747,0.00004724087,0.0002693246],"domain_scores_gemma":[0.9995278,0.000006318671,0.00007819755,0.0002682071,0.00007011446,0.00004940501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007557969,0.00005774571,0.003846175,0.00004936098,0.00002739581,0.000005556366,0.000368241,0.00002488837,0.9934124,0.000001110059,0.001968339,0.0001632053],"study_design_scores_gemma":[0.0004972689,0.000109176,0.005982335,0.00002353419,0.00002363101,0.0001849693,0.0001649334,0.00001496892,0.9894574,0.000006297023,0.003265455,0.0002700704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960484,0.003193775,0.00002587669,0.0001098543,0.000131842,0.0001870893,0.00001043912,0.00001815582,0.0002745715],"genre_scores_gemma":[0.9961334,0.001535215,0.0004655306,0.0001134737,0.0001289698,0.000004283022,0.000159529,0.00003081526,0.001428821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003955042,"threshold_uncertainty_score":0.8542063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006130587459720418,"score_gpt":0.1878261773127268,"score_spread":0.1816955898530064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}