{"id":"W2052474126","doi":"10.1002/cpt.77","title":"Blood–brain barrier: An impediment to neuropharmaceuticals","year":2015,"lang":"en","type":"editorial","venue":"Clinical Pharmacology & Therapeutics","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Drug Policy Research Network; University of Toronto","funders":"","keywords":"Blood–brain barrier; Central nervous system; Medicine; Systemic circulation; Drug; Drug delivery; Neuroscience; Site of action; Blood circulation; Intensive care medicine; Pharmacology; Biology; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001880892,0.0009574664,0.001525847,0.0002301212,0.0004484616,0.0001326382,0.00163932,0.001736485,0.0006786378],"category_scores_gemma":[0.00172251,0.0008372797,0.0004508636,0.0005192969,0.001089749,0.0001769097,0.0008169918,0.004091028,0.0007243321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001085369,"about_ca_system_score_gemma":0.0009363178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003536642,"about_ca_topic_score_gemma":0.000002777457,"domain_scores_codex":[0.9908334,0.002764256,0.001677189,0.002182252,0.001349696,0.001193223],"domain_scores_gemma":[0.9880443,0.008243237,0.000514352,0.0009413341,0.0006189507,0.001637871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008965221,0.0004917456,0.00004056243,0.00002428484,0.000462754,0.0001645426,0.0002421029,0.00001163208,0.03555341,0.00001113622,0.9594661,0.002635218],"study_design_scores_gemma":[0.003137194,0.002529139,0.00001537524,0.00001049114,0.002352183,0.000009341492,0.00002871195,0.00005569163,0.0102744,0.0002611381,0.9805301,0.0007962071],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.006893766,0.0007813873,0.00006554453,0.01012757,0.9791023,0.001132792,0.0006542632,0.0004478781,0.0007945294],"genre_scores_gemma":[0.00164478,0.002219542,0.000128163,0.2438647,0.7491478,0.0001578456,0.00004679802,0.0001994701,0.00259089],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.2337371,"threshold_uncertainty_score":0.9995595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1644587133161838,"score_gpt":0.4914402294245855,"score_spread":0.3269815161084017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}