{"id":"W2052474126","doi":"10.1002/cpt.77","title":"Blood–brain barrier: An impediment to neuropharmaceuticals","year":2015,"lang":"en","type":"editorial","venue":"Clinical Pharmacology & Therapeutics","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Drug Policy Research Network; University of Toronto","funders":"","keywords":"Blood–brain barrier; Central nervous system; Medicine; Systemic circulation; Drug; Drug delivery; Neuroscience; Site of action; Blood circulation; Intensive care medicine; Pharmacology; Biology; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006084234,0.003243207,0.002924882,0.001930237,0.001844013,0.005984425,0.003712826,0.01388437,0.004781975],"category_scores_gemma":[0.01298366,0.001031929,0.001927922,0.001063603,0.003520329,0.005358694,0.002121695,0.02474084,0.00539026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002472111,"about_ca_system_score_gemma":0.002137802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009983963,"about_ca_topic_score_gemma":0.002542292,"domain_scores_codex":[0.9962423,0.0006215253,0.0006035882,0.0004509437,0.00184642,0.0002353294],"domain_scores_gemma":[0.9897684,0.004666236,0.0006006881,0.0003016221,0.003547545,0.001115428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005184854,0.00001943964,0.00003039907,0.0006746356,0.00003223724,0.0002440428,0.00002561532,0.00005231203,0.0002540974,0.001234403,0.9770772,0.02030368],"study_design_scores_gemma":[0.00003724818,0.00003912927,0.0001092353,0.000430071,0.00003936841,0.0004550728,0.0000276896,0.0001082525,0.0002425456,0.001423906,0.9970708,0.0000166889],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00007205197,0.04165738,0.0003410384,0.03452753,0.9220995,0.00001608428,0.00002520624,0.00005803452,0.001203011],"genre_scores_gemma":[0.0007371044,0.04623717,0.000246611,0.02300218,0.9228761,0.00001802466,0.00002403479,0.00003235452,0.006826499],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01388437,"threshold_uncertainty_score":0.03217691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1644587133161838,"score_gpt":0.4914402294245855,"score_spread":0.3269815161084017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}