{"id":"W2052475624","doi":"10.1634/stemcells.20-2-119","title":"Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130‐Mediated Embryonic Stem Cell Self‐Renewal Responses to LIF and HIL‐6","year":2002,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences; Massachusetts Institute of Technology; National Science Foundation","keywords":"Biology; Leukemia inhibitory factor; Glycoprotein 130; Cytokine receptor; Embryonic stem cell; Stem cell factor; Cell biology; Cytokine; Receptor; Stem cell; Embryoid body; Signal transduction; Immunology; Biochemistry; Interleukin 6; Adult stem cell; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004981809,0.0003916158,0.0003622698,0.000197739,0.0002204756,0.0001406932,0.0004803752,0.0003604194,0.00002854303],"category_scores_gemma":[0.000014916,0.0003836472,0.0001552225,0.000243288,0.00006128676,0.00001538379,0.0003194923,0.0001801011,0.0002052511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007030887,"about_ca_system_score_gemma":0.0001228678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005783274,"about_ca_topic_score_gemma":0.000009847883,"domain_scores_codex":[0.9973498,0.0001015257,0.0004034779,0.0009048245,0.0004157966,0.0008245779],"domain_scores_gemma":[0.9985412,0.0001288462,0.0001261763,0.0005845635,0.000216225,0.0004029822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003588496,0.0001366175,0.0002154865,0.0001760606,0.00006468604,0.000005666666,0.0002546656,0.0009636808,0.9844391,0.000007438628,0.01306555,0.0003121489],"study_design_scores_gemma":[0.001352087,0.0005205825,0.000005715545,0.00004501297,0.0000363636,0.000005199085,0.0001534019,0.01232897,0.9591409,0.00001139556,0.0259096,0.0004908016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934121,0.002944354,0.0006278214,0.0002653204,0.0002392296,0.001131516,0.0004264104,0.00006234098,0.0008908847],"genre_scores_gemma":[0.9646999,0.0007472619,0.0008668973,0.0003539405,0.0002637366,0.0001398227,0.00007908366,0.00009809319,0.03275129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03186041,"threshold_uncertainty_score":0.9998615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02469857180958195,"score_gpt":0.2500476663644036,"score_spread":0.2253490945548217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}