{"id":"W2052475624","doi":"10.1634/stemcells.20-2-119","title":"Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130‐Mediated Embryonic Stem Cell Self‐Renewal Responses to LIF and HIL‐6","year":2002,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences; Massachusetts Institute of Technology; National Science Foundation","keywords":"Biology; Leukemia inhibitory factor; Glycoprotein 130; Cytokine receptor; Embryonic stem cell; Stem cell factor; Cell biology; Cytokine; Receptor; Stem cell; Embryoid body; Signal transduction; Immunology; Biochemistry; Interleukin 6; Adult stem cell; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002358438,0.0004909068,0.0006331393,0.0004485231,0.000364217,0.000876861,0.001332099,0.001318092,0.003592638],"category_scores_gemma":[0.000874456,0.0003738004,0.0007460148,0.0003008934,0.0003753139,0.0008944836,0.0004126889,0.0005242789,0.000633666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00093227,"about_ca_system_score_gemma":0.001052629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004984383,"about_ca_topic_score_gemma":0.002165877,"domain_scores_codex":[0.999859,0.00002612355,0.000006641641,0.00002692362,0.00003950438,0.00004178694],"domain_scores_gemma":[0.9997244,0.0001326627,0.00004059239,0.00001469283,0.00005247958,0.000035151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00009659272,0.0000538705,0.0005633103,0.00005987749,0.00001864461,0.0001734075,0.00003721699,0.9725206,0.01257586,0.01104536,0.0004539889,0.002401129],"study_design_scores_gemma":[0.00001251635,0.0000145272,0.0000895857,0.000002130821,0.000008193034,0.00001867654,0.000003815889,0.9972655,0.0009038095,0.001435037,0.0002422078,0.000004089808],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.561433,0.001211808,0.3759716,0.001096182,0.0001679729,0.0002539733,0.001138029,0.001447181,0.0572802],"genre_scores_gemma":[0.9735847,0.0004626383,0.01516179,0.0002502193,0.00002209687,0.0003903839,0.0004379983,0.0001068334,0.009583429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004984383,"threshold_uncertainty_score":0.01201856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02469857180958195,"score_gpt":0.2500476663644036,"score_spread":0.2253490945548217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}