{"id":"W2052521716","doi":"10.1016/j.jpeds.2007.04.009","title":"High-Dose Ibuprofen in Cystic Fibrosis: Canadian Safety and Effectiveness Trial","year":2007,"lang":"en","type":"article","venue":"The Journal of Pediatrics","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Université de Sherbrooke; Centre for Advancing Health Outcomes; Montreal Children's Hospital; Hospital for Sick Children; University of British Columbia; McGill University","funders":"","keywords":"Medicine; Ibuprofen; Placebo; Cystic fibrosis; Adverse effect; Vital capacity; Clinical endpoint; Internal medicine; Randomized controlled trial; Respiratory disease; Clinical trial; Lung; Anesthesia; Surgery; Lung function; Diffusing capacity; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002649702,0.001087262,0.002225327,0.0004911164,0.001819082,0.001562503,0.001369233,0.002307261,0.003998023],"category_scores_gemma":[0.005206539,0.0005184895,0.00156932,0.001401805,0.002047329,0.0007663957,0.0004787,0.002795734,0.0003593382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01783719,"about_ca_system_score_gemma":0.03416447,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.4625888,"about_ca_topic_score_gemma":0.6646905,"domain_scores_codex":[0.9978648,0.000893613,0.0001018588,0.0002332399,0.0004922228,0.0004143638],"domain_scores_gemma":[0.9953623,0.0008627744,0.0008008412,0.0002048866,0.001042396,0.001726774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.883985,0.005718005,0.0144599,0.001762246,0.003497732,0.0002945506,0.0002773779,0.000764449,0.002127226,0.001919766,0.02082021,0.06437352],"study_design_scores_gemma":[0.9163687,0.02357008,0.03840523,0.0005385109,0.004928558,0.0001701717,0.0002098008,0.0006410105,0.0006549949,0.0005820348,0.01382068,0.0001102989],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9061152,0.04149478,0.0005567778,0.01436367,0.0009051068,0.002897949,0.01070223,0.0001028452,0.02286152],"genre_scores_gemma":[0.9688966,0.01708716,0.001450782,0.004400911,0.000526435,0.0007865276,0.003347816,0.00002385097,0.003479811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5374112,"threshold_uncertainty_score":0.9197924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072917768476796,"score_gpt":0.2995534122863837,"score_spread":0.2888242346016157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}