{"id":"W2052522969","doi":"10.1182/blood-2007-08-105221","title":"Cytotoxic T lymphocytes overcome Bcl-2 inhibition: target cells contribute to their own demise","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; National Cancer Institute; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Cytotoxic T cell; Granzyme; Cell biology; Granzyme B; Apoptosis; Biology; Programmed cell death; Mitochondrion; Perforin; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385378,0.0003914825,0.0003691139,0.00024513,0.0001607332,0.0006877892,0.0002716939,0.0004183719,0.002340882],"category_scores_gemma":[0.0002377216,0.0001197915,0.0001654667,0.0001119061,0.0002265914,0.0005924611,0.0004667197,0.0009917279,0.0006552619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263835,"about_ca_system_score_gemma":0.0001886162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009242387,"about_ca_topic_score_gemma":0.0001730359,"domain_scores_codex":[0.9998009,0.00003838141,0.000010623,0.0000237367,0.00004506867,0.00008143172],"domain_scores_gemma":[0.9998404,0.00003750445,0.00002786127,0.00002653477,0.00002481996,0.00004288861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003628511,0.0001171061,0.0005053143,0.0001021194,0.00001047565,0.0002628579,0.00005406349,0.00017034,0.9845776,0.001058176,0.0001599084,0.01261928],"study_design_scores_gemma":[0.0001619707,0.001006512,0.002466568,0.00002348056,0.00004957497,0.00153774,0.00006736579,0.001576627,0.9840742,0.0009320243,0.008098301,0.00000555004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823031,0.00677369,0.004968836,0.0004048234,0.00006091212,0.00004707463,0.000040487,0.0002019002,0.00519922],"genre_scores_gemma":[0.9954294,0.001006709,0.0008672378,0.0001322119,0.00003824714,0.00001882805,0.00004320853,0.0000139919,0.002450286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002340882,"threshold_uncertainty_score":0.007831037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005662453170986241,"score_gpt":0.2122476375191416,"score_spread":0.2065851843481554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}