{"id":"W2052524261","doi":"10.1093/neuonc/nou273.6","title":"RM-06 * IN VITRO CLONAL EVOLUTION OF GLIOBLASTOMA (GBM) BRAIN TUMOUR INITIATING CELLS (BTIC) TO MODEL TUMOUR RECURRENCE","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Ontario Institute for Cancer Research","funders":"","keywords":"Temozolomide; Biology; Somatic evolution in cancer; Transcriptome; SOX2; Stem cell; Glioblastoma; Cancer research; Radiation therapy; Genetic heterogeneity; Cancer stem cell; Brain tumor; Oncology; Internal medicine; Pathology; Medicine; Cancer; Gene; Phenotype; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004439989,0.0004449206,0.0004320996,0.0004221717,0.0002221654,0.000412806,0.0004459885,0.0005456481,0.001719002],"category_scores_gemma":[0.0001794113,0.0002010287,0.0004828449,0.0002810666,0.0001889385,0.0001553332,0.0003164188,0.001164638,0.00122836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004345891,"about_ca_system_score_gemma":0.0003941774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002554939,"about_ca_topic_score_gemma":0.003728619,"domain_scores_codex":[0.9994745,0.0001126056,0.0000648694,0.00009774003,0.0001772154,0.00007328136],"domain_scores_gemma":[0.9996504,0.00006853761,0.00006122978,0.00006957869,0.00007040988,0.00007987666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001968993,0.0002748425,0.0004263405,0.00009004046,0.00001328375,0.000131181,0.0000572736,0.0008031167,0.9933436,0.000584921,0.0007663667,0.003312073],"study_design_scores_gemma":[0.00004976369,0.002197854,0.003624998,0.00002931131,0.00004713913,0.0005367968,0.0000492641,0.007500497,0.9665519,0.0001624318,0.01923414,0.00001591293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468462,0.003452304,0.02610004,0.0005811342,0.0003316232,0.0007538972,0.005097688,0.0007048966,0.01613217],"genre_scores_gemma":[0.9309387,0.002036443,0.03835095,0.0003895838,0.0000469152,0.000998653,0.007276974,0.0002044239,0.01975734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002554939,"threshold_uncertainty_score":0.005750597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251037475513437,"score_gpt":0.297776598291746,"score_spread":0.2752662235366116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}