{"id":"W2052525016","doi":"10.1371/journal.pgen.1004592","title":"Systematic Dissection of Coding Exons at Single Nucleotide Resolution Supports an Additional Role in Cell-Specific Transcriptional Regulation","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Sandler Foundation; Canadian Institutes of Health Research; National Human Genome Research Institute; University of California, San Francisco; National Institutes of Health; Amgen","keywords":"Biology; Enhancer; Exon; Genetics; Gene; Mutation; Transcription factor; Transcription (linguistics); Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001689314,0.000253314,0.000225629,0.000260878,0.0001763373,0.0003039333,0.0002195584,0.0003113674,0.0008887834],"category_scores_gemma":[0.0002217214,0.0001818415,0.0003234692,0.0001930261,0.0003218094,0.000291514,0.0002354052,0.0007979464,0.0004751477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001985335,"about_ca_system_score_gemma":0.0002085808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000369089,"about_ca_topic_score_gemma":0.001073917,"domain_scores_codex":[0.9999197,0.000006975974,0.000007763203,0.00003412319,0.00002124447,0.00001030806],"domain_scores_gemma":[0.9996526,0.0001080083,0.0001110208,0.00006661421,0.00003197931,0.00002970898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001970475,0.000004635945,0.0003676309,0.00002528712,0.000003899512,0.00004634754,0.00001002894,0.0001199292,0.9979814,0.0002405136,0.000008194085,0.001172283],"study_design_scores_gemma":[0.000004220803,0.00008062684,0.01187042,0.00001082905,0.00002118633,0.0006425298,0.00003521003,0.001844405,0.9817993,0.000530051,0.003152645,0.000008601673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438384,0.001373357,0.05195968,0.0001395327,0.00003989981,0.00003185634,0.0009358732,0.0002045583,0.001476825],"genre_scores_gemma":[0.9566678,0.001169505,0.03918309,0.00007493862,0.00001167911,0.00003293407,0.001251827,0.00007724533,0.001531035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008887834,"threshold_uncertainty_score":0.002973318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009272893371718341,"score_gpt":0.1881248148487771,"score_spread":0.1788519214770588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}