{"id":"W2052528763","doi":"10.1007/s00018-014-1688-y","title":"Differential evolution of signal-responsive RNA elements and upstream factors that control alternative splicing","year":2014,"lang":"en","type":"review","venue":"Cellular and Molecular Life Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Biology; RNA splicing; Alternative splicing; Conserved sequence; Vertebrate; Exon; Gene; Intron; RNA; Evolutionary biology; Trans-splicing; Genetics; Computational biology; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006214062,0.0007368582,0.0009427973,0.001088259,0.0001535691,0.0009335988,0.0009045813,0.001031192,0.00116878],"category_scores_gemma":[0.0005155212,0.0002650844,0.0003011821,0.001548709,0.0008078323,0.001053532,0.0006568105,0.001377909,0.0008365398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006318144,"about_ca_system_score_gemma":0.0006644321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000480295,"about_ca_topic_score_gemma":0.0008220522,"domain_scores_codex":[0.9998658,0.00001396422,0.00001551949,0.00004365487,0.00004329585,0.00001781113],"domain_scores_gemma":[0.999805,0.00009236574,0.0000323505,0.000009782071,0.00004363178,0.00001693109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001044855,0.00002762657,0.0004475168,0.005974592,0.00007797968,0.000325047,0.00006141053,0.0005945535,0.01777891,0.01002308,0.008160269,0.9564245],"study_design_scores_gemma":[0.00002226564,0.00006605093,0.002290812,0.001350105,0.0001550697,0.001791723,0.00009606579,0.0002133635,0.008228839,0.007926453,0.9778217,0.00003759448],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008209389,0.9958627,0.001022713,0.0003740337,0.0002352655,0.000004537245,0.00003560433,0.00001371583,0.001630522],"genre_scores_gemma":[0.003376143,0.9940085,0.001022538,0.000341666,0.0002208924,0.000006538362,0.00007378176,0.000004783541,0.0009451029],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00116878,"threshold_uncertainty_score":0.004584134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02324552392936681,"score_gpt":0.3041694044659423,"score_spread":0.2809238805365755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}