{"id":"W2052548963","doi":"10.1016/j.molimm.2005.11.016","title":"Autoreactivity of primary human immunoglobulins ancestral to hypermutated human antibodies that neutralize HCMV","year":2006,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia","funders":"","keywords":"Antibody; Epitope; Biology; Gene; Virology; Germline; Genetics; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002742459,0.000267694,0.0001561053,0.0002738185,0.000225578,0.0002821548,0.0002840499,0.0004218587,0.002407776],"category_scores_gemma":[0.0004870814,0.0001300744,0.0002212626,0.0001461526,0.0002819155,0.0001792883,0.0002808199,0.0006731443,0.0002986236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003331025,"about_ca_system_score_gemma":0.0001459199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000633595,"about_ca_topic_score_gemma":0.0004883584,"domain_scores_codex":[0.9998158,0.00004575874,0.00001028258,0.00003129864,0.00003113252,0.00006581986],"domain_scores_gemma":[0.999749,0.00009413417,0.00002522136,0.0000584275,0.00003595106,0.00003711378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001816326,0.00005065326,0.002725153,0.00001661386,0.00002172688,0.0003138456,0.00006024771,0.0001307794,0.9932243,0.0005782851,0.00008117637,0.002615575],"study_design_scores_gemma":[0.000100026,0.001091006,0.07470295,0.00002367874,0.0001443323,0.007582542,0.0002771916,0.002834579,0.9045526,0.0009975516,0.007676811,0.00001669279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973028,0.000187599,0.0004471052,0.00002511932,0.00001510497,0.000005209748,0.00003090307,0.00001713829,0.001968989],"genre_scores_gemma":[0.9988769,0.0001141803,0.0001999649,0.0000565767,0.00001098898,0.000004060896,0.0001087326,0.000007911639,0.0006207743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002407776,"threshold_uncertainty_score":0.008054852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03278164177143518,"score_gpt":0.3231049744689902,"score_spread":0.2903233326975551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}